Glycobiology of cell death: When glycans and lectins govern cell fate

R. G. Lichtenstein, G. A. Rabinovich

Research output: Contribution to journalReview articlepeer-review

69 Scopus citations


Although one typically thinks of carbohydrates as associated with cell growth and viability, glycosylation also has an integral role in many processes leading to cell death. Glycans, either alone or complexed with glycan-binding proteins, can deliver intracellular signals or control extracellular processes that promote initiation, execution and resolution of cell death programs. Herein, we review the role of glycans and glycan-binding proteins as essential components of the cell death machinery during physiologic and pathologic settings.

Original languageEnglish
Pages (from-to)976-986
Number of pages11
JournalCell Death and Differentiation
Issue number8
StatePublished - 1 Aug 2013


  • Apoptosis
  • Autophagy
  • Galectins
  • Glycans
  • Lectins

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology


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