Glycobiology of cell death: When glycans and lectins govern cell fate

R. G. Lichtenstein, G. A. Rabinovich

Research output: Contribution to journalReview articlepeer-review

60 Scopus citations

Abstract

Although one typically thinks of carbohydrates as associated with cell growth and viability, glycosylation also has an integral role in many processes leading to cell death. Glycans, either alone or complexed with glycan-binding proteins, can deliver intracellular signals or control extracellular processes that promote initiation, execution and resolution of cell death programs. Herein, we review the role of glycans and glycan-binding proteins as essential components of the cell death machinery during physiologic and pathologic settings.

Original languageEnglish
Pages (from-to)976-986
Number of pages11
JournalCell Death and Differentiation
Volume20
Issue number8
DOIs
StatePublished - 1 Aug 2013

Keywords

  • Apoptosis
  • Autophagy
  • Galectins
  • Glycans
  • Lectins

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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