GnRH agonist versus GnRH antagonist in ovarian stimulation: An ongoing debate

Raoul Orvieto, Pasquale Patrizio

Research output: Contribution to journalReview articlepeer-review

51 Scopus citations


The availability of gonadotrophin-releasing hormone (GnRH) antagonists for ovarian stimulation protocols has generated many meta-analyses comparing it to GnRH agonist long protocols. These meta-analyses have yielded conflicting results for pregnancy rate, with a tendency toward a better outcome for GnRH agonists. Recently, a Cochrane review seems to have settled the conflicts by demonstrating no evidence of statistically significant differences in the rates of live births or ongoing pregnancies when comparing GnRH agonist long protocols with GnRH antagonist protocols. This paper disputes the equivalence of these two protocols as discussed in the latest meta-analysis and argue that the GnRH agonist still has a demonstrable superiority over GnRH antagonist protocols.

Original languageEnglish
Pages (from-to)4-8
Number of pages5
JournalReproductive BioMedicine Online
Issue number1
StatePublished - 1 Jan 2013


  • GnRH agonist
  • GnRH antagonist
  • IVF outcome
  • Pregnancy

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology
  • Developmental Biology


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