Gold nanoparticles based imaging technique and drug delivery for the detection and treatment of atherosclerotic vascular disease

Rinat Ankri, Dorit Leshem-Lev, Eli I. Lev, Menachem Motiei, Edith Hochhauser, Dror Fixler

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations

Abstract

In our study we aim to develop a new, simple and non-invasive method to detect and to treat atherosclerosis. We use gold nanoparticles (GNPs) combined with the diffusion reflection (DR) method to demonstrate the detection of vulnerable atherosclerotic plaques. Our method is based on the fact that macrophages are a major component in the vulnerable plaque and are able to uptake metal nanoparticles that can be discovered by the DR system. Moreover, it is well known that high density lipoprotein (HDL) reduces ASVD by inhibiting pro-inflammatory factors, enabling the specific treatment of atherosclerosis.

Original languageEnglish
Title of host publicationNanoscale Imaging, Sensing, and Actuation for Biomedical Applications XIII
EditorsAlexander N. Cartwright, Dan V. Nicolau
PublisherSPIE
ISBN (Electronic)9781628419559
DOIs
StatePublished - 1 Jan 2016
Externally publishedYes
EventNanoscale Imaging, Sensing, and Actuation for Biomedical Applications XIII - San Francisco, United States
Duration: 15 Feb 201617 Feb 2016

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume9721
ISSN (Print)1605-7422

Conference

ConferenceNanoscale Imaging, Sensing, and Actuation for Biomedical Applications XIII
Country/TerritoryUnited States
CitySan Francisco
Period15/02/1617/02/16

Keywords

  • Biomolecular imaging
  • Gold nano particles uptake
  • High density lipoprotein
  • Macrophages
  • Noninvasive detection

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