Gold nanorods as absorption contrast agents for the noninvasive detection of arterial vascular disorders based on diffusion reflection measurements

Rinat Ankri; Dorit Leshem-Lev; Dror Fixler; Rachela Popovtzer; Menachem Motiei; Ran Kornowski; Edith Hochhauser; Eli I. Lev

doi:10.1021/nl500573d

Gold nanorods as absorption contrast agents for the noninvasive detection of arterial vascular disorders based on diffusion reflection measurements

Rinat Ankri, Dorit Leshem-Lev, Dror Fixler, Rachela Popovtzer, Menachem Motiei, Ran Kornowski, Edith Hochhauser, Eli I. Lev

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

In this study we report the use of gold nanorods (GNRs) as absorption contrast agents in the diffusion reflection (DR) method for the in vivo detection of atherosclerotic injury. The early detection and characterization of atherosclerotic vascular disease is considered to be one of the greatest medical challenges today. We show that macrophage cells, which are major components of unstable active atherosclerotic plaques, uptake gold nanoparticles, resulting in a change in the optical properties of tissue-like phantoms and a unique DR profile. In vivo DR measurements of rats that underwent injury of the carotid artery showed a clear difference between the DR profiles of the injured compared with healthy arteries. The results suggest that DR measurements following GNRs administration represent a potential novel method for the early detection of atherosclerotic vascular disease.

Original language	English
Pages (from-to)	2681-2687
Number of pages	7
Journal	Nano Letters
Volume	14
Issue number	5
DOIs	https://doi.org/10.1021/nl500573d
State	Published - 14 May 2014
Externally published	Yes

Keywords

Gold nanoparticles
biomolecular imaging
gold nanorods
macrophages
noninvasive detection

ASJC Scopus subject areas

Bioengineering
General Chemistry
General Materials Science
Condensed Matter Physics
Mechanical Engineering

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/nl500573d

Cite this

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title = "Gold nanorods as absorption contrast agents for the noninvasive detection of arterial vascular disorders based on diffusion reflection measurements",

abstract = "In this study we report the use of gold nanorods (GNRs) as absorption contrast agents in the diffusion reflection (DR) method for the in vivo detection of atherosclerotic injury. The early detection and characterization of atherosclerotic vascular disease is considered to be one of the greatest medical challenges today. We show that macrophage cells, which are major components of unstable active atherosclerotic plaques, uptake gold nanoparticles, resulting in a change in the optical properties of tissue-like phantoms and a unique DR profile. In vivo DR measurements of rats that underwent injury of the carotid artery showed a clear difference between the DR profiles of the injured compared with healthy arteries. The results suggest that DR measurements following GNRs administration represent a potential novel method for the early detection of atherosclerotic vascular disease.",

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author = "Rinat Ankri and Dorit Leshem-Lev and Dror Fixler and Rachela Popovtzer and Menachem Motiei and Ran Kornowski and Edith Hochhauser and Lev, {Eli I.}",

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doi = "10.1021/nl500573d",

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T1 - Gold nanorods as absorption contrast agents for the noninvasive detection of arterial vascular disorders based on diffusion reflection measurements

AU - Ankri, Rinat

AU - Leshem-Lev, Dorit

AU - Fixler, Dror

AU - Popovtzer, Rachela

AU - Motiei, Menachem

AU - Kornowski, Ran

AU - Hochhauser, Edith

AU - Lev, Eli I.

PY - 2014/5/14

Y1 - 2014/5/14

N2 - In this study we report the use of gold nanorods (GNRs) as absorption contrast agents in the diffusion reflection (DR) method for the in vivo detection of atherosclerotic injury. The early detection and characterization of atherosclerotic vascular disease is considered to be one of the greatest medical challenges today. We show that macrophage cells, which are major components of unstable active atherosclerotic plaques, uptake gold nanoparticles, resulting in a change in the optical properties of tissue-like phantoms and a unique DR profile. In vivo DR measurements of rats that underwent injury of the carotid artery showed a clear difference between the DR profiles of the injured compared with healthy arteries. The results suggest that DR measurements following GNRs administration represent a potential novel method for the early detection of atherosclerotic vascular disease.

AB - In this study we report the use of gold nanorods (GNRs) as absorption contrast agents in the diffusion reflection (DR) method for the in vivo detection of atherosclerotic injury. The early detection and characterization of atherosclerotic vascular disease is considered to be one of the greatest medical challenges today. We show that macrophage cells, which are major components of unstable active atherosclerotic plaques, uptake gold nanoparticles, resulting in a change in the optical properties of tissue-like phantoms and a unique DR profile. In vivo DR measurements of rats that underwent injury of the carotid artery showed a clear difference between the DR profiles of the injured compared with healthy arteries. The results suggest that DR measurements following GNRs administration represent a potential novel method for the early detection of atherosclerotic vascular disease.

KW - Gold nanoparticles

KW - biomolecular imaging

KW - gold nanorods

KW - macrophages

KW - noninvasive detection

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JF - Nano Letters

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Gold nanorods as absorption contrast agents for the noninvasive detection of arterial vascular disorders based on diffusion reflection measurements

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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