Gonadotoxicity and kinetics of dibromochloropropane in male rats

Drora Shemi; Uriel A. Sod-Moriah; Jacob Kaplanski; Gad Potashnik; Amram P. Bitan; Ouri Buchman

doi:10.1016/0378-4274(87)90187-1

Gonadotoxicity and kinetics of dibromochloropropane in male rats

Drora Shemi
, Uriel A. Sod-Moriah
, Jacob Kaplanski
, Gad Potashnik
, Amram P. Bitan
, Ouri Buchman

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Adult male rats were injected with [³H]dibromochloropropane dissolved in dimethylsulfoxide containing about 10 × 10⁶ dpm. Blood from the tail and 24-h urine samples were collected up to 2 days postinjection. Tissue samples were further taken from the kidneys, liver, spleen, adrenals, epididymis, seminal vesicles and testes 7 h and 7 days post-injection. The results demonstrate that (a) there is no preference in labelling of the testes compared with other organs, and (b) the kidney and liver may have an important role in the elimination of DBCP.

Original language	English
Pages (from-to)	209-212
Number of pages	4
Journal	Toxicology Letters
Volume	36
Issue number	3
DOIs	https://doi.org/10.1016/0378-4274(87)90187-1
State	Published - 1 Jan 1987

Keywords

DBCP
rat
testes

ASJC Scopus subject areas

Toxicology

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10.1016/0378-4274(87)90187-1

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title = "Gonadotoxicity and kinetics of dibromochloropropane in male rats",

abstract = "Adult male rats were injected with [3H]dibromochloropropane dissolved in dimethylsulfoxide containing about 10 {\texttimes} 106 dpm. Blood from the tail and 24-h urine samples were collected up to 2 days postinjection. Tissue samples were further taken from the kidneys, liver, spleen, adrenals, epididymis, seminal vesicles and testes 7 h and 7 days post-injection. The results demonstrate that (a) there is no preference in labelling of the testes compared with other organs, and (b) the kidney and liver may have an important role in the elimination of DBCP.",

keywords = "DBCP, rat, testes",

author = "Drora Shemi and Sod-Moriah, \{Uriel A.\} and Jacob Kaplanski and Gad Potashnik and Bitan, \{Amram P.\} and Ouri Buchman",

year = "1987",

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doi = "10.1016/0378-4274(87)90187-1",

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T1 - Gonadotoxicity and kinetics of dibromochloropropane in male rats

AU - Shemi, Drora

AU - Sod-Moriah, Uriel A.

AU - Kaplanski, Jacob

AU - Potashnik, Gad

AU - Bitan, Amram P.

AU - Buchman, Ouri

PY - 1987/1/1

Y1 - 1987/1/1

N2 - Adult male rats were injected with [3H]dibromochloropropane dissolved in dimethylsulfoxide containing about 10 × 106 dpm. Blood from the tail and 24-h urine samples were collected up to 2 days postinjection. Tissue samples were further taken from the kidneys, liver, spleen, adrenals, epididymis, seminal vesicles and testes 7 h and 7 days post-injection. The results demonstrate that (a) there is no preference in labelling of the testes compared with other organs, and (b) the kidney and liver may have an important role in the elimination of DBCP.

AB - Adult male rats were injected with [3H]dibromochloropropane dissolved in dimethylsulfoxide containing about 10 × 106 dpm. Blood from the tail and 24-h urine samples were collected up to 2 days postinjection. Tissue samples were further taken from the kidneys, liver, spleen, adrenals, epididymis, seminal vesicles and testes 7 h and 7 days post-injection. The results demonstrate that (a) there is no preference in labelling of the testes compared with other organs, and (b) the kidney and liver may have an important role in the elimination of DBCP.

KW - DBCP

KW - rat

KW - testes

UR - https://www.scopus.com/pages/publications/0023275122

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DO - 10.1016/0378-4274(87)90187-1

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SN - 0378-4274

VL - 36

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EP - 212

JO - Toxicology Letters

JF - Toxicology Letters

IS - 3

ER -

Gonadotoxicity and kinetics of dibromochloropropane in male rats

Abstract

Keywords

ASJC Scopus subject areas

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