Gonadotoxicity and kinetics of dibromochloropropane in male rats

Drora Shemi, Uriel A. Sod-Moriah, Jacob Kaplanski, Gad Potashnik, Amram P. Bitan, Ouri Buchman

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Adult male rats were injected with [3H]dibromochloropropane dissolved in dimethylsulfoxide containing about 10 × 106 dpm. Blood from the tail and 24-h urine samples were collected up to 2 days postinjection. Tissue samples were further taken from the kidneys, liver, spleen, adrenals, epididymis, seminal vesicles and testes 7 h and 7 days post-injection. The results demonstrate that (a) there is no preference in labelling of the testes compared with other organs, and (b) the kidney and liver may have an important role in the elimination of DBCP.

Original languageEnglish
Pages (from-to)209-212
Number of pages4
JournalToxicology Letters
Volume36
Issue number3
DOIs
StatePublished - 1 Jan 1987

Keywords

  • DBCP
  • rat
  • testes

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