Gonadotropin stimulation following GnRH-a priming for poor responders in in vitro fertilization - Embryo transfer programs

H. Pinkas, R. Orvieto, O. M. Avrech, O. Rufas, A. Ferber, Z. Ben-Rafael, B. Fisch

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

The effect of ganadotropin-releasing hormone agonist (GnRH-a) administration before gonadotropin super-ovulation on the stimulation characteristics of poor responder patients was assessed in an in vitro fertilization (IVF) program. Thirty consecutive patients who had exhibited low ovarian response (fewer than four retrieved oocytes) in at least two previous IVF cycler (control cycles, n = 60), were eligible for the study. GnRH-a (nafarelin) was administered daily for 7-10 days from the mid-luteal phase of the previous cycle until the first day of menstruation. Menotropin treatment was commenced on cycle day 3 (with no additional GnRH-a) (study cycles, n = 39). A significantly higher number of oocytes was retrieved (p < 0.0002) and a higher number of embryos transferred (p < 0.003) in the study cycles than in the control cycles. No cases of premature luteinizing hormone surge were recorded. Pregnancy rates per embryo transfer and per cycle were 10.4% and 7.7% for the study cycles and 2.8% and 1.6% for the control cycles, respectively. GnRH-a, administered prior to gonadotropin treatment, should be an additional option of ovulation induction protocol for poor responders in IVF programs.

Original languageEnglish
Pages (from-to)11-14
Number of pages4
JournalGynecological Endocrinology
Volume14
Issue number1
DOIs
StatePublished - 1 Jan 2000

Keywords

  • IVF-ET
  • Ovulation induction
  • Poor responders

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