Gonadotropins and glucocorticoid therapy for "low responders" - A controlled study

D. Bider, J. Blankstein, J. Levron, I. Tur-Kaspa

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Purpose: A randomized, nonplacebo controlled study was conducted to determine the effect of dexamethasone supplementation to a protocol of gonadotropin therapy in 42 "low-responder patients" aged 32 to 43 years. Methods: All underwent at least two previous cycles treated by gonadotropins for unexplained infertility, or anovulation. Human menopausal gonadotropin was started on day 4 of the menstrual cycle combined with dexamethasone 0.5 mg administered nightly, as an adjuvant. A group of "low responders" who did not receive dexamethasone served as the controls. The number of follicles, total amount of gonadotropins used, time required for stimulation, fertilization, peak estradiol levels and pregnancy rate were evaluated. Results: The number of developing follicles, estradiol levels, fertilization rate and pregnancy rate did not differ significantly. Conclusions: Although certain beneficial effects were observed in the literature in some of the infertile patients treated with corticosteroids, the overall results did not support daily, low-dose dexamethasone (long-acting corticosteroid) as a clinically useful adjuvant therapy for "low responders" during gonadotropin therapy.

Original languageEnglish
Pages (from-to)328-331
Number of pages4
JournalJournal of Assisted Reproduction and Genetics
Volume14
Issue number6
DOIs
StatePublished - 1 Jan 1997
Externally publishedYes

Keywords

  • Glucocorticoids
  • Gonadotropins
  • Low responders

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