Graphene Oxide Synergistically Enhances Antibiotic Efficacy in Vancomycin-Resistant Staphylococcus aureus

Vimal Singh, Vinod Kumar, Sunayana Kashyap, Ajay Vikram Singh, Vimal Kishore, Metin Sitti, Preeti S. Saxena, Anchal Srivastava

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

The current study highlights a new polyvalent inhibitor approach based on Vancomycin conjugated with graphene oxide (Van@GO) against a Vancomycin-resistant Staphylococcus aureus (VRSA) strain. Physicochemical characteristics of the prepared Van@GO composites were studied using UV-vis and FTIR spectroscopy techniques. Characterization results confirm the attachment of Vancomycin to the graphene oxide. A significant inhibition of VRSA growth is achieved by Vancomycin when presented as Van@GO. The polyvalent inhibition activity of Van@GO was characterized by performing bacteriological experiments along with scanning electron microscopy. Results clearly exhibit the enhanced inhibition activity of Van@GO compared to Vancomycin alone against VRSA. The high surface area of GO facilitates high loading and multivalent interaction of conjugated Vancomycin leading to polyvalent inhibition. Further, we found that Van@GO significantly reduces the motility of VRSA via inducing oxidative stress compared with untreated samples. Our findings highlight the importance of Van@GO as an effective polyvalent inhibition recipe for VRSA.

Original languageEnglish
Pages (from-to)1148-1157
Number of pages10
JournalACS Applied Bio Materials
Volume2
Issue number3
DOIs
StatePublished - 18 Mar 2019
Externally publishedYes

Keywords

  • graphene oxide
  • multivalent interactions
  • polyvalent inhibitors
  • vancomycin

ASJC Scopus subject areas

  • Chemistry (all)
  • Biomaterials
  • Biomedical Engineering
  • Biochemistry, medical

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