Greater intake of the MEDI diet is associated with better cognitive trajectory in older adults with type 2 diabetes

Roni Lotan, Ramit Ravona-Springer, Jacob Mandel, Hung Mo Lin, Yuxia Ouyang, Danit R. Shahar, Sharon Bezalel, Puja Agarwal, Klodian Dhana, Anthony Heymann, Mary Sano, Michal Schnaider Beeri

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Aims: To determine associations of three dietary patterns (Mediterranean (MEDI) diet, the Dietary Approaches to Stop Hypertension (DASH) diet and the Mediterranean- DASH Intervention for Neurodegenerative Delay (MIND) diet) with cognitive decline in older adults with type 2 diabetes mellitus (T2D). Methods: This is a longitudinal observational study. Participants (N = 960) from the Israel Diabetes and Cognitive Decline (IDCD) study were included in this study. A multivariable-adjusted model including all three dietary patterns concurrently was developed to investigate their independent effect on cognitive decline. Results: The mean follow up was 4.1 ± 2.1 years. While high adherence to both the MIND and the MEDI diet was associated with a slower decline, in the multivariable model only the associations of higher MEDI diet intake with greater decline in global cognition and in executive functions remained significant (β = 0.013, SE = 0.006; P = 0.042; β = 0.001, SE = 0.008, Pv = 0.023 respectively). Conclusions: In older adults with T2D, adherence to the MEDI is related to better cognitive trajectory. Diet is a meaningful factor in the path linking T2D and cognition.

Original languageEnglish
Article number109989
JournalDiabetes Research and Clinical Practice
StatePublished - 1 Aug 2022


  • Cognitive decline
  • Dietary patterns
  • Older adults
  • Type 2 diabetes

ASJC Scopus subject areas

  • Endocrinology
  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism


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