TY - JOUR
T1 - Green coffee ameliorates components of diet-induced metabolic syndrome in rats
AU - Bhandarkar, Nikhil S.
AU - Mouatt, Peter
AU - Brown, Lindsay
AU - Panchal, Sunil K.
N1 - Funding Information:
We would like to thank Brain Bynon, School of Veterinary Sciences, The University of Queensland, Gatton, for plasma biochemical analyses. This study was supported by funding received from the University of Southern Queensland Research and Innovation Division .
Publisher Copyright:
© 2019 Elsevier Ltd
PY - 2019/6/1
Y1 - 2019/6/1
N2 - Metabolic syndrome, especially obesity, increases the risk of type 2 diabetes and cardiovascular disease. We hypothesised that green coffee will attenuate metabolic, cardiovascular and liver parameters in high-carbohydrate high-fat diet-fed rats. Male Wistar rats (8–9 weeks old) were divided into 6 groups and fed for 16 weeks with either corn starch diet (C), C with either 5% green or decaffeinated green coffee in food for the last 8 weeks, high-carbohydrate high-fat diet (H) or H with either 5% green or decaffeinated green coffee in food for the last 8 weeks. Green coffee contained chlorogenic acids, trigonelline, caffeine and diterpenoids; decaffeinated green coffee contained these compounds but no caffeine. Green coffee attenuated body weight, systolic blood pressure, inflammation in the heart and liver and diastolic stiffness without improving glucose sensitivity or plasma lipids. We suggest that chlorogenic acids, trigonelline and diterpenoids in green coffee attenuate diet-induced abnormalities in heart and liver.
AB - Metabolic syndrome, especially obesity, increases the risk of type 2 diabetes and cardiovascular disease. We hypothesised that green coffee will attenuate metabolic, cardiovascular and liver parameters in high-carbohydrate high-fat diet-fed rats. Male Wistar rats (8–9 weeks old) were divided into 6 groups and fed for 16 weeks with either corn starch diet (C), C with either 5% green or decaffeinated green coffee in food for the last 8 weeks, high-carbohydrate high-fat diet (H) or H with either 5% green or decaffeinated green coffee in food for the last 8 weeks. Green coffee contained chlorogenic acids, trigonelline, caffeine and diterpenoids; decaffeinated green coffee contained these compounds but no caffeine. Green coffee attenuated body weight, systolic blood pressure, inflammation in the heart and liver and diastolic stiffness without improving glucose sensitivity or plasma lipids. We suggest that chlorogenic acids, trigonelline and diterpenoids in green coffee attenuate diet-induced abnormalities in heart and liver.
KW - Cardiovascular disease
KW - Green coffee
KW - High-carbohydrate, high-fat diet
KW - Metabolic syndrome
KW - Obesity
UR - http://www.scopus.com/inward/record.url?scp=85064093436&partnerID=8YFLogxK
U2 - 10.1016/j.jff.2019.04.003
DO - 10.1016/j.jff.2019.04.003
M3 - Article
AN - SCOPUS:85064093436
SN - 1756-4646
VL - 57
SP - 141
EP - 149
JO - Journal of Functional Foods
JF - Journal of Functional Foods
ER -
