Growth Plate Suppression in an Adolescent Patient with Acute Lymphoblastic Leukemia after Treatment

Ekaterina Tiktinsky, Daniel Levin, Sophia Lantsberg, Joseph Kapelushnik

    Research output: Contribution to journalArticlepeer-review

    1 Scopus citations

    Abstract

    Osteotoxic effect is a common adverse effect of chemotherapy for childhood acute lymphoblastic leukemia. The pathophysiology of impaired bone growth is multifactorial and can affect both osteoblast and osteoclast function. Significant contribution in affecting skeletal metabolism belongs to high-dose corticosteroid treatment. We present the case of a 12-year-old adolescent girl who was treated for high-risk pro-B acute lymphoblastic leukemia. The Tc-MDP bone scan, as a sensitive indicator of osteoblastic activity, shows that growth plate inhibition after intensive treatment may be temporary and reversible.

    Original languageEnglish
    Pages (from-to)495-496
    Number of pages2
    JournalClinical Nuclear Medicine
    Volume43
    Issue number7
    DOIs
    StatePublished - 1 Jul 2018

    Keywords

    • acute lymphoblastic leukemia
    • glucocorticoid treatment
    • growth plates

    ASJC Scopus subject areas

    • Radiology Nuclear Medicine and imaging

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