TY - JOUR
T1 - Growth Plate Suppression in an Adolescent Patient with Acute Lymphoblastic Leukemia after Treatment
AU - Tiktinsky, Ekaterina
AU - Levin, Daniel
AU - Lantsberg, Sophia
AU - Kapelushnik, Joseph
N1 - Publisher Copyright:
© 2018 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2018/7/1
Y1 - 2018/7/1
N2 - Osteotoxic effect is a common adverse effect of chemotherapy for childhood acute lymphoblastic leukemia. The pathophysiology of impaired bone growth is multifactorial and can affect both osteoblast and osteoclast function. Significant contribution in affecting skeletal metabolism belongs to high-dose corticosteroid treatment. We present the case of a 12-year-old adolescent girl who was treated for high-risk pro-B acute lymphoblastic leukemia. The Tc-MDP bone scan, as a sensitive indicator of osteoblastic activity, shows that growth plate inhibition after intensive treatment may be temporary and reversible.
AB - Osteotoxic effect is a common adverse effect of chemotherapy for childhood acute lymphoblastic leukemia. The pathophysiology of impaired bone growth is multifactorial and can affect both osteoblast and osteoclast function. Significant contribution in affecting skeletal metabolism belongs to high-dose corticosteroid treatment. We present the case of a 12-year-old adolescent girl who was treated for high-risk pro-B acute lymphoblastic leukemia. The Tc-MDP bone scan, as a sensitive indicator of osteoblastic activity, shows that growth plate inhibition after intensive treatment may be temporary and reversible.
KW - acute lymphoblastic leukemia
KW - glucocorticoid treatment
KW - growth plates
UR - http://www.scopus.com/inward/record.url?scp=85048708109&partnerID=8YFLogxK
U2 - 10.1097/RLU.0000000000002126
DO - 10.1097/RLU.0000000000002126
M3 - Article
C2 - 29762237
AN - SCOPUS:85048708109
SN - 0363-9762
VL - 43
SP - 495
EP - 496
JO - Clinical Nuclear Medicine
JF - Clinical Nuclear Medicine
IS - 7
ER -