H-coil repetitive transcranial magnetic stimulation for the treatment of bipolar depression: An add-on, safety and feasibility study

Eiran Vadim Harel, Abraham Zangen, Yiftach Roth, Irving Reti, Yoram Braw, Yechiel Levkovitz

Research output: Contribution to journalArticlepeer-review

84 Scopus citations

Abstract

Objectives. The H1-Coil is a novel transcranial magnetic stimulation (TMS) device capable of inducing a magnetic fi eld with a deeper and wider distribution than standard coils. This pilot study evaluated the safety and feasibility of the H1-Coil as adjuvant treatment for bipolar depression (BPD). Methods. Nineteen patients diagnosed as having BPD and under treatment with psychotropic medication were enrolled in the study. They received daily prefrontal repetitive TMS (rTMS: 20 Hz, 2 s on, 20 s off, totaling 1680 stimuli) every weekday for four consecutive weeks. The primary outcome measure was the change from baseline in the Hamilton Depression Rating Scale (HDRS-24) score a week after the last treatment session. Results. A signifi cant mean decrease of 12.9 points in the HDRS-24 scale ( P= 0.001) was found. Response rate was 63.2% and remission rate was 52.6%. Treatment was well tolerated in terms of headache and overall discomfort, and there were no signifi cant change in cognitive functioning or mood switches. One patient had a short induced generalized seizure without complications. Conclusions. An add-on H-coil rTMS treatment protocol in BPD subjects indicated improvement in bipolar depression symptoms. Sham-control studies to further determine the effi cacy and safety of the H-Coil for BPD are warranted.

Original languageEnglish
Pages (from-to)119-126
Number of pages8
JournalWorld Journal of Biological Psychiatry
Volume12
Issue number2
DOIs
StatePublished - 1 Mar 2011
Externally publishedYes

Keywords

  • Affective disorder
  • Bipolar depression
  • Cognitive function
  • Transcranial magnetic stimulation

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