H5-type influenza virus hemagglutinin is functionally recognized by the natural killer-activating receptor NKp44

Joanna W. Ho, Oren Hershkovitz, Malik Peiris, Alon Zilka, Ahuva Bar-Ilan, Beatrice Nal, Kid Chu, Mateusz Kudelko, Wing Kam Yiu, Hagit Achdout, Michal Mandelboim, Ralf Altmeyer, Ofer Mandelboim, Roberto Bruzzone, Angel Porgador

Research output: Contribution to journalArticlepeer-review

62 Scopus citations

Abstract

Antiviral immune defenses involve natural killer (NK) cells. We previously showed that the NK-activating receptor NKp44 is involved in the functional recognition of H1-type influenza virus strains by NK cells. In the present study, we investigated the interaction of NKp44 and the hemagglutinin of a primary influenza virus H5N1 isolate. Here we show that recombinant NKp44 recognizes H5-expressing cells and specifically interacts with soluble H5 hemagglutinin. H5-pseudotyped lentiviral particles bind to NK cells expressing NKp44. Following interaction with target cells expressing H5, pseudotyped lentiviral particles, or membrane-associated H5, NK cells show NKp44-mediated induced activity. These findings indicate that NKp44-H5 interactions induce functional NK activation.

Original languageEnglish
Pages (from-to)2028-2032
Number of pages5
JournalJournal of Virology
Volume82
Issue number4
DOIs
StatePublished - 1 Feb 2008

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