Haemodynamics and oxygenation in the lower-limb muscles of young ambulatory adults with cerebral palsy

Ronit Aviram, Inbar Kima, Yisrael Parmet, Haim Bassan, Thierry Willigenburg, Raziel Riemer, Simona Ben-Haim

Research output: Contribution to journalArticlepeer-review


To evaluate muscle haemodynamics and oxygen metabolism in adults with cerebral palsy (CP) at rest and during exercise.

This cross-sectional study included 12 adults with spastic CP (four females, eight males; mean age [SD] 29 years 6 months [7 years 10.8 months]) and 13 typically developing individuals (seven females, six males; mean age [SD] 26 years 6 months [1 year 1.9 months]). Near-infrared spectroscopy was used to assess changes in muscle blood flow (mBF), muscle oxygen consumption (mVO2), and muscle oxygen saturation in the vastus lateralis and rectus femoris muscles during three conditions: rest, low load at 20% maximum voluntary contraction (MVC), and high load at 80% MVC.

MBF was lower in participants with CP than in typically developing participants at rest (p 
Oxidative metabolism in CP is not limited by oxygen delivery (mBF), because high muscle saturation suggests oxygen availability. Adults with CP demonstrate muscular responses to exercise that are inconsistent with typical high-workload activation, probably because of inefficient fibre recruitment and secondary anomalies.
Original languageEnglish
Pages (from-to)978-987
Number of pages10
JournalDevelopmental Medicine and Child Neurology
Issue number7
StatePublished - 16 Jan 2023

ASJC Scopus subject areas

  • Clinical Neurology
  • Developmental Neuroscience
  • Pediatrics, Perinatology, and Child Health


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