Hairy cell leukemia: Retrospective analysis of demographic data and outcome of 203 patients from 12 medical centers in Israel

Michal Inbar, Yair Herishanu, Neta Goldschmidt, Osnat Bairey, Mona Yuklea, Lev Shvidel, Riva Fineman, Ariel Aviv, Rosa Ruchlemer, Andrei Braester, Dally Najib, Ory Rouvio, Adir Shaulov, Uri Greenbaum, Aaron Polliack, Tamar Tadmor

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Background/Aim: In this retrospective study, we summarized the national Israeli experience with hairy cell leukemia (HCL) in a large cohort of patients with a long followup. Patients and Methods: Demographic data, and relevant laboratory and clinical parameters were analyzed, emphasizing the outcome after first-line treatment with cladribine. Results: Data on 203 patients was collected from 12 medical centers during 1985-2015. Mean and median follow-up were 7.5 years and 5.18 years (interquartile range=0.1-40 years), and 5- and 10-year survival were 96% and 90.62%, respectively. The median age of diagnosis was 55.5 years for Jews and 49 years for Arabs (p=0.021), and most patients were males (81.77%); 52.2% were Ashkenazi Jews, 36.1% Sephardic Jews and 11.7% were Arab, Druze or other ethnicity. Cladribine was given to 159 patients (80.7%%) and most (62%) received intravenous (i.v.) and 38% received subcutaneous (s.c.) therapy. Overall survival and time to next treatment were not significantly different between the two schedules (i.v., s.c.). In univariate analysis of a variety of factors, only age >65 years had a negative impact on outcome, with shorter overall survival. It is of interest that Arab patients with HCL were diagnosed at an earlier age, but had a similar clinical course and outcome to both Ashkenazi and Sephardic Jews.

Original languageEnglish
Pages (from-to)6423-6429
Number of pages7
JournalAnticancer Research
Volume38
Issue number11
DOIs
StatePublished - 1 Nov 2018
Externally publishedYes

Keywords

  • Cladribine
  • Ethnicity
  • HCL
  • Hairy cell leukemia
  • Intravenous
  • Subcutaneous

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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