TY - JOUR
T1 - Haloferax volcanii PitA
T2 - An example of functional interaction between the Pfam chlorite dismutase and antibiotic biosynthesis monooxygenase families?
AU - Bab-Dinitz, Elizabeta
AU - Shmuely, Hagay
AU - Maupin-Furlow, Julie
AU - Eichler, Jerry
AU - Shaanan, Boaz
N1 - Funding Information:
J.E. is supported by the ISF (grant 433/03). J.M-F. is supported by NIH (R01 GM057498) and DOE (DE-FG02-05ER15650).
PY - 2006/3/15
Y1 - 2006/3/15
N2 - A curious fusion between chlorite dismutase-like and antibiotic biosynthesis monooxygenase-like domains within a single open reading frame has been revealed by both sequence homology and structural modeling in Haloferax volcanii PitA and its homologues in other halophilic archaea. While this fusion may reflect an environmental adaptation to life in hypersaline environments and hence one specific to haloarchaea, PitA and its homologues may represent a paradigm of biologically-relevant interplay between these two distinct activities in accordance with the Rosetta Stone approach.
AB - A curious fusion between chlorite dismutase-like and antibiotic biosynthesis monooxygenase-like domains within a single open reading frame has been revealed by both sequence homology and structural modeling in Haloferax volcanii PitA and its homologues in other halophilic archaea. While this fusion may reflect an environmental adaptation to life in hypersaline environments and hence one specific to haloarchaea, PitA and its homologues may represent a paradigm of biologically-relevant interplay between these two distinct activities in accordance with the Rosetta Stone approach.
UR - http://www.scopus.com/inward/record.url?scp=33645104904&partnerID=8YFLogxK
U2 - 10.1093/bioinformatics/btk043
DO - 10.1093/bioinformatics/btk043
M3 - Article
C2 - 16403788
AN - SCOPUS:33645104904
SN - 1367-4803
VL - 22
SP - 671
EP - 675
JO - Bioinformatics
JF - Bioinformatics
IS - 6
ER -