Haloperidol blood levels during dosage reduction in chronic schizophrenic patients

Zalman Goldman; Richard P. Ebstein; Bernard Lerer; Joseph Zohar; Mira Hermoni; Robert H. Belmaker

doi:10.1159/000117861

Haloperidol blood levels during dosage reduction in chronic schizophrenic patients

Zalman Goldman, Richard P. Ebstein, Bernard Lerer, Joseph Zohar, Mira Hermoni, Robert H. Belmaker

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Haloperidol levels were measured by radioreceptor assay in 12 schizophrenic patients during gradual dosage reduction (at 10-day intervals) from 60 to 0 mg/day. Serum levels were highly correlated with the oral dose in each patient, but poorly correlated across patients. Clinical deterioration appeared only 10-20 days after total cessation of the oral drug, and so it was not possible to determine an optimal blood level for chronic maintenance. Below oral dosage of 10 mg/day of haloperidol many patients’ blood levels are undetectable by the radioreceptor method.

Original language	English
Pages (from-to)	281-284
Number of pages	4
Journal	Neuropsychobiology
Volume	7
Issue number	6
DOIs	https://doi.org/10.1159/000117861
State	Published - 1 Jan 1981
Externally published	Yes

Keywords

Blood levels
Drug holiday
Haloperidol
Schizophrenia

ASJC Scopus subject areas

Neuropsychology and Physiological Psychology
Psychiatry and Mental health
Biological Psychiatry

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10.1159/000117861

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title = "Haloperidol blood levels during dosage reduction in chronic schizophrenic patients",

abstract = "Haloperidol levels were measured by radioreceptor assay in 12 schizophrenic patients during gradual dosage reduction (at 10-day intervals) from 60 to 0 mg/day. Serum levels were highly correlated with the oral dose in each patient, but poorly correlated across patients. Clinical deterioration appeared only 10-20 days after total cessation of the oral drug, and so it was not possible to determine an optimal blood level for chronic maintenance. Below oral dosage of 10 mg/day of haloperidol many patients{\textquoteright} blood levels are undetectable by the radioreceptor method.",

keywords = "Blood levels, Drug holiday, Haloperidol, Schizophrenia",

author = "Zalman Goldman and Ebstein, {Richard P.} and Bernard Lerer and Joseph Zohar and Mira Hermoni and Belmaker, {Robert H.}",

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doi = "10.1159/000117861",

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T1 - Haloperidol blood levels during dosage reduction in chronic schizophrenic patients

AU - Goldman, Zalman

AU - Ebstein, Richard P.

AU - Lerer, Bernard

AU - Zohar, Joseph

AU - Hermoni, Mira

AU - Belmaker, Robert H.

PY - 1981/1/1

Y1 - 1981/1/1

N2 - Haloperidol levels were measured by radioreceptor assay in 12 schizophrenic patients during gradual dosage reduction (at 10-day intervals) from 60 to 0 mg/day. Serum levels were highly correlated with the oral dose in each patient, but poorly correlated across patients. Clinical deterioration appeared only 10-20 days after total cessation of the oral drug, and so it was not possible to determine an optimal blood level for chronic maintenance. Below oral dosage of 10 mg/day of haloperidol many patients’ blood levels are undetectable by the radioreceptor method.

AB - Haloperidol levels were measured by radioreceptor assay in 12 schizophrenic patients during gradual dosage reduction (at 10-day intervals) from 60 to 0 mg/day. Serum levels were highly correlated with the oral dose in each patient, but poorly correlated across patients. Clinical deterioration appeared only 10-20 days after total cessation of the oral drug, and so it was not possible to determine an optimal blood level for chronic maintenance. Below oral dosage of 10 mg/day of haloperidol many patients’ blood levels are undetectable by the radioreceptor method.

KW - Blood levels

KW - Drug holiday

KW - Haloperidol

KW - Schizophrenia

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DO - 10.1159/000117861

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VL - 7

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EP - 284

JO - Neuropsychobiology

JF - Neuropsychobiology

IS - 6

ER -

Haloperidol blood levels during dosage reduction in chronic schizophrenic patients

Abstract

Keywords

ASJC Scopus subject areas

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