Haloperidol blood levels during dosage reduction in chronic schizophrenic patients

Zalman Goldman, Richard P. Ebstein, Bernard Lerer, Joseph Zohar, Mira Hermoni, Robert H. Belmaker

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Haloperidol levels were measured by radioreceptor assay in 12 schizophrenic patients during gradual dosage reduction (at 10-day intervals) from 60 to 0 mg/day. Serum levels were highly correlated with the oral dose in each patient, but poorly correlated across patients. Clinical deterioration appeared only 10-20 days after total cessation of the oral drug, and so it was not possible to determine an optimal blood level for chronic maintenance. Below oral dosage of 10 mg/day of haloperidol many patients’ blood levels are undetectable by the radioreceptor method.

Original languageEnglish
Pages (from-to)281-284
Number of pages4
JournalNeuropsychobiology
Volume7
Issue number6
DOIs
StatePublished - 1 Jan 1981
Externally publishedYes

Keywords

  • Blood levels
  • Drug holiday
  • Haloperidol
  • Schizophrenia

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Psychiatry and Mental health
  • Biological Psychiatry

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