Harnessing the mesenchymal stem cell secretome for the treatment of cardiovascular disease

Sudhir H. Ranganath, Oren Levy, Maneesha S. Inamdar, Jeffrey M. Karp

Research output: Contribution to journalReview articlepeer-review

688 Scopus citations

Abstract

The broad repertoire of secreted trophic and immunomodulatory cytokines produced by mesenchymal stem cells (MSCs), generally referred to as the MSC secretome, has considerable potential for the treatment of cardiovascular disease. However, harnessing this MSC secretome for meaningful therapeutic outcomes is challenging due to the limited control of cytokine production following their transplantation. This review outlines the current understanding of the MSC secretome as a therapeutic for treatment of ischemic heart disease. We discuss ongoing investigative directions aimed at improving cellular activity and characterizing the secretome and its regulation in greater detail. Finally, we provide insights on and perspectives for future development of the MSC secretome as a therapeutic tool.

Original languageEnglish
Pages (from-to)244-258
Number of pages15
JournalCell Stem Cell
Volume10
Issue number3
DOIs
StatePublished - 2 Mar 2012
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Cell Biology

Fingerprint

Dive into the research topics of 'Harnessing the mesenchymal stem cell secretome for the treatment of cardiovascular disease'. Together they form a unique fingerprint.

Cite this