TY - JOUR
T1 - Harnessing the mesenchymal stem cell secretome for the treatment of cardiovascular disease
AU - Ranganath, Sudhir H.
AU - Levy, Oren
AU - Inamdar, Maneesha S.
AU - Karp, Jeffrey M.
PY - 2012/3/2
Y1 - 2012/3/2
N2 - The broad repertoire of secreted trophic and immunomodulatory cytokines produced by mesenchymal stem cells (MSCs), generally referred to as the MSC secretome, has considerable potential for the treatment of cardiovascular disease. However, harnessing this MSC secretome for meaningful therapeutic outcomes is challenging due to the limited control of cytokine production following their transplantation. This review outlines the current understanding of the MSC secretome as a therapeutic for treatment of ischemic heart disease. We discuss ongoing investigative directions aimed at improving cellular activity and characterizing the secretome and its regulation in greater detail. Finally, we provide insights on and perspectives for future development of the MSC secretome as a therapeutic tool.
AB - The broad repertoire of secreted trophic and immunomodulatory cytokines produced by mesenchymal stem cells (MSCs), generally referred to as the MSC secretome, has considerable potential for the treatment of cardiovascular disease. However, harnessing this MSC secretome for meaningful therapeutic outcomes is challenging due to the limited control of cytokine production following their transplantation. This review outlines the current understanding of the MSC secretome as a therapeutic for treatment of ischemic heart disease. We discuss ongoing investigative directions aimed at improving cellular activity and characterizing the secretome and its regulation in greater detail. Finally, we provide insights on and perspectives for future development of the MSC secretome as a therapeutic tool.
UR - http://www.scopus.com/inward/record.url?scp=84857838864&partnerID=8YFLogxK
U2 - 10.1016/j.stem.2012.02.005
DO - 10.1016/j.stem.2012.02.005
M3 - Review article
C2 - 22385653
AN - SCOPUS:84857838864
SN - 1934-5909
VL - 10
SP - 244
EP - 258
JO - Cell Stem Cell
JF - Cell Stem Cell
IS - 3
ER -