Harnessing the oxidation susceptibility of deubiquitinases for inhibition with small molecules

Keyphrases

• Small Molecules 100%
• Deubiquitinase 100%
• Oxidation Sensitivity 100%
• Reactive Oxygen Species 33%
• Novel Mechanism 16%
• Biological Processes 16%
• Therapeutic Effect 16%
• Clinical Trials 16%
• Oxidative Stress 16%
• Potent Inhibitor 16%
• Cellular Targets 16%
• Cancer Therapy 16%
• Ubiquitination 16%
• Ubiquitin Chains 16%
• Diverse Roles 16%
• Non-reversible 16%
• Reversible Oxidation 16%
• β-Lapachone 16%

Biochemistry, Genetics and Molecular Biology

• Alpha Oxidation 100%
• Small Molecule 100%
• Biological Phenomena and Functions Concerning the Entire Organism 33%
• Oxidative Stress 33%
• Clinical Trial 33%
• Ubiquitination 33%
• Ubiquitin 33%

Pharmacology, Toxicology and Pharmaceutical Science

• Deubiquitinase 100%
• Malignant Neoplasm 33%
• Reactive Oxygen Metabolite 33%
• Therapeutic Effect 16%
• Disease 16%
• Ubiquitin 16%
• Clinical Trial 16%
• Beta Lapachone 16%