Harnessing the power of transition metals in solid-phase peptide synthesis and key steps in the (semi)synthesis of proteins

Shay Laps, Gandhesiri Satish, Ashraf Brik

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations

Abstract

Peptides and proteins can be either synthesized using solid-phase peptide synthesis (SPPS) or by applying a combination of SPPS and ligation approaches to address fundamental questions related to human health and disease, among others. The demand for their production either by chemical or biological methods continues to raise significant interests from the synthetic community. In this context, transition metals such as Pd, Ag, Hg, Tl, Au, Zn, Ni, and Cu have also contributed to the field of peptide and protein synthesis such as in peptide conjugation, extending native chemical ligation (NCL), and for regioselective disulfide bonds formation. In this review, we highlight, summarize, and evaluate the use of various transition metals in the chemical synthesis of peptides and proteins with emphasis on recent developments in this exciting research area.

Original languageEnglish
Pages (from-to)2367-2387
Number of pages21
JournalChemical Society Reviews
Volume50
Issue number4
DOIs
StatePublished - 21 Feb 2021
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry (all)

Fingerprint

Dive into the research topics of 'Harnessing the power of transition metals in solid-phase peptide synthesis and key steps in the (semi)synthesis of proteins'. Together they form a unique fingerprint.

Cite this