TY - JOUR
T1 - Hematological ratios as an indicator of severity in alopecia areata
T2 - A retrospective nationwide study
AU - Andre, Nicolas
AU - Weissmann, Sarah
AU - Cohen, Bracha
AU - Gordon, Chaya Bracha
AU - Nassar, Majd
AU - Kestenbom, Inbal
AU - Golan-Tripto, Inbal
AU - Horev, Amir
N1 - Publisher Copyright:
© 2024 Andre et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2024/12/1
Y1 - 2024/12/1
N2 - Background Alopecia Areata (AA) is an autoimmune condition where the activation of Th1, Th2, and Th17 responses is known to stimulate other white blood cells, potentially affecting hematopoietic lineages. However, previous studies on AA have found no utility in hematological ratios. Our goals were to compare neutrophils-to-lymphocytes ratio (NLR), platelets-to-lymphocytes ratio (PLR), eosinophils-to-lymphocytes ratio (ELR), eosinophils-to-neutrophils ratio (ENR), and eosinophils-to-monocytes ratio (EMR) between patients with AA and controls, as well as between mild and moderate-severe AA cases. Methods and findings We performed a retrospective, population-based cohort study involving adult patients enrolled in the largest national health maintenance organization in Israel. The study comprised 147,020 AA patients and 141,598 healthy controls. AA patients exhibited a higher likelihood of elevated NLR and ELR compared to controls. Upon further classification based on severity, moderate-severe AA patients displayed higher values of NLR, PLR, ELR, and EMR compared to mild AA individuals OR = 1.11 [1.09–1.1], P<0.001; OR = 1.09 [1.05–1.13], P<0.001; OR = 2.06 [1.67–2.53], P<0.001; OR = 1.07 [1.03–1.07)], P<0.001, respectively). Similar trends were observed 12 to 18 months before diagnosis. Conclusion Our results not only deviate from the current literature but also offer a cost-effective, accessible, and efficient tool for enhanced disease prediction and management.
AB - Background Alopecia Areata (AA) is an autoimmune condition where the activation of Th1, Th2, and Th17 responses is known to stimulate other white blood cells, potentially affecting hematopoietic lineages. However, previous studies on AA have found no utility in hematological ratios. Our goals were to compare neutrophils-to-lymphocytes ratio (NLR), platelets-to-lymphocytes ratio (PLR), eosinophils-to-lymphocytes ratio (ELR), eosinophils-to-neutrophils ratio (ENR), and eosinophils-to-monocytes ratio (EMR) between patients with AA and controls, as well as between mild and moderate-severe AA cases. Methods and findings We performed a retrospective, population-based cohort study involving adult patients enrolled in the largest national health maintenance organization in Israel. The study comprised 147,020 AA patients and 141,598 healthy controls. AA patients exhibited a higher likelihood of elevated NLR and ELR compared to controls. Upon further classification based on severity, moderate-severe AA patients displayed higher values of NLR, PLR, ELR, and EMR compared to mild AA individuals OR = 1.11 [1.09–1.1], P<0.001; OR = 1.09 [1.05–1.13], P<0.001; OR = 2.06 [1.67–2.53], P<0.001; OR = 1.07 [1.03–1.07)], P<0.001, respectively). Similar trends were observed 12 to 18 months before diagnosis. Conclusion Our results not only deviate from the current literature but also offer a cost-effective, accessible, and efficient tool for enhanced disease prediction and management.
UR - https://www.scopus.com/pages/publications/85211132938
U2 - 10.1371/journal.pone.0314600
DO - 10.1371/journal.pone.0314600
M3 - Article
C2 - 39621703
AN - SCOPUS:85211132938
SN - 1932-6203
VL - 19
JO - PLOS ONE
JF - PLOS ONE
IS - 12
M1 - e0314600
ER -