Hematopoietic Stem Cells and the Aging Hematopoietic System

Roi Gazit, Irving L. Weissman, Derrick J. Rossi

Research output: Contribution to journalArticlepeer-review

76 Scopus citations

Abstract

The etiology of the age-associated pathophysiological changes of the hematopoietic system including the onset of anemia, diminished adaptive immune competence, and myelogenous disease development are underwritten by the loss of normal homeostatic control. As tissue and organ homeostasis in adults is primarily mediated by the activity of stem and progenitor cells, it has been suggested that the imbalances accompanying aging of the hematopoietic system may stem from alterations in the prevalence and/or functional capacity of hematopoietic stem cells (HSCs) and progenitors. In this review, we examine evidence implicating a role for stem cells in the aging of the hematopoietic system, and focus on the mechanisms suggested to contribute to stem cell aging.

Original languageEnglish
Pages (from-to)218-224
Number of pages7
JournalSeminars in Hematology
Volume45
Issue number4
DOIs
StatePublished - 1 Oct 2008
Externally publishedYes

ASJC Scopus subject areas

  • Hematology

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