Hemodynamic studies in a parabiotic model of portal hypertension

E. Sikuler; R. J. Groszmann

doi:10.1007/BF01952076

Hemodynamic studies in a parabiotic model of portal hypertension

E. Sikuler, R. J. Groszmann

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Splanchnic and systemic hemodynamic studies were performed in a rat model of parabiosis and portal hypertension. A portal hypertensive and a normal rat were surgically united side to side. A hyperdynamic circulation, characterized by increased cardiac index (413±26 vs 318±23 ml·min^-1·kg^-1; p<0.05) and portal venous inflow (9.61±1.29 vs 6.33±0.36 ml·min^-1·100 g b.wt^-1; p<0.05), was found in all the portal hypertensive rats but not in the normal parabiotic partners. These results do not support the existence of a transferable humoral factor mediating the hyperdynamic circulatory state of chronic portal hypertension.

Original language	English
Pages (from-to)	1323-1324
Number of pages	2
Journal	Experientia
Volume	41
Issue number	10
DOIs	https://doi.org/10.1007/BF01952076
State	Published - 1 Oct 1985
Externally published	Yes

Keywords

Parabiosis
hyperdynamic circulation
portal hypertension

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1007/BF01952076

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title = "Hemodynamic studies in a parabiotic model of portal hypertension",

abstract = "Splanchnic and systemic hemodynamic studies were performed in a rat model of parabiosis and portal hypertension. A portal hypertensive and a normal rat were surgically united side to side. A hyperdynamic circulation, characterized by increased cardiac index (413±26 vs 318±23 ml·min-1·kg-1; p<0.05) and portal venous inflow (9.61±1.29 vs 6.33±0.36 ml·min-1·100 g b.wt-1; p<0.05), was found in all the portal hypertensive rats but not in the normal parabiotic partners. These results do not support the existence of a transferable humoral factor mediating the hyperdynamic circulatory state of chronic portal hypertension.",

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year = "1985",

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AU - Sikuler, E.

AU - Groszmann, R. J.

PY - 1985/10/1

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N2 - Splanchnic and systemic hemodynamic studies were performed in a rat model of parabiosis and portal hypertension. A portal hypertensive and a normal rat were surgically united side to side. A hyperdynamic circulation, characterized by increased cardiac index (413±26 vs 318±23 ml·min-1·kg-1; p<0.05) and portal venous inflow (9.61±1.29 vs 6.33±0.36 ml·min-1·100 g b.wt-1; p<0.05), was found in all the portal hypertensive rats but not in the normal parabiotic partners. These results do not support the existence of a transferable humoral factor mediating the hyperdynamic circulatory state of chronic portal hypertension.

AB - Splanchnic and systemic hemodynamic studies were performed in a rat model of parabiosis and portal hypertension. A portal hypertensive and a normal rat were surgically united side to side. A hyperdynamic circulation, characterized by increased cardiac index (413±26 vs 318±23 ml·min-1·kg-1; p<0.05) and portal venous inflow (9.61±1.29 vs 6.33±0.36 ml·min-1·100 g b.wt-1; p<0.05), was found in all the portal hypertensive rats but not in the normal parabiotic partners. These results do not support the existence of a transferable humoral factor mediating the hyperdynamic circulatory state of chronic portal hypertension.

KW - Parabiosis

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ER -

Hemodynamic studies in a parabiotic model of portal hypertension

Abstract

Keywords

ASJC Scopus subject areas

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