Hemodynamic studies in a parabiotic model of portal hypertension

E. Sikuler, R. J. Groszmann

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Splanchnic and systemic hemodynamic studies were performed in a rat model of parabiosis and portal hypertension. A portal hypertensive and a normal rat were surgically united side to side. A hyperdynamic circulation, characterized by increased cardiac index (413±26 vs 318±23 ml·min-1·kg-1; p<0.05) and portal venous inflow (9.61±1.29 vs 6.33±0.36 ml·min-1·100 g b.wt-1; p<0.05), was found in all the portal hypertensive rats but not in the normal parabiotic partners. These results do not support the existence of a transferable humoral factor mediating the hyperdynamic circulatory state of chronic portal hypertension.

Original languageEnglish
Pages (from-to)1323-1324
Number of pages2
JournalExperientia
Volume41
Issue number10
DOIs
StatePublished - 1 Oct 1985
Externally publishedYes

Keywords

  • Parabiosis
  • hyperdynamic circulation
  • portal hypertension

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology

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