Hemophagocytic lymphohistiocytosis associated with parechovirus 3 infection

Shraga Aviner, Danit Sofer, Lester M. Shulman, Haim Bibi, Sheila Weitzman

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Hemophagocytic lymphohistiocytosis (HLH) denotes the common final pathway of a potentially fatal hyperinflammatory condition of diverse etiologies. We describe the first case of documented HLH associated with human parechovirus 3. A monoallelic Ala91Val mutation was found in the PRF1 gene, but the contribution of this mutation to HLH remains controversial. The diagnosis, based on accepted criteria, was established early in the course of the disease and led to successful treatment and complete recovery. The awareness of this new association is clinically important in facilitating early treatment, preventing organ damage, and increasing the likelihood of complete recovery.

Original languageEnglish
Pages (from-to)e251-e253
JournalJournal of Pediatric Hematology/Oncology
Issue number4
StatePublished - 1 Jan 2014


  • hemophagocytic lymphohistiocytosis
  • human parechovirus
  • meningitis
  • neonate

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology


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