Abstract
Fetal and adult human growth hormone (HGH) extract from human pituitaries as well as plasma from premature and full term newborns and children were submitted to chromatography on Sephadex G 75 and the immunoreactive HGH (IRHGH) in the elution fractions was determined quantitatively by radioimmunoassay. Three fractions of IRHGH could be differentiated according to the elution pattern: 'big big', 'big' and 'little' IRHGH. In fetal pituitary extract only 'big big' and 'little' IRHGH were found, whereas in adult pituitary extract all 3 forms of IRHGH were present. In the plasma samples studied no 'big big' form was found; only 'big' and 'little' IRHGH appeared. In addition, plasma samples of premature newborns had a smaller proportion of the 'big' IRHGH than did those of the full term newborns and older children.
| Original language | English |
|---|---|
| Pages (from-to) | 354-359 |
| Number of pages | 6 |
| Journal | Neonatology |
| Volume | 29 |
| Issue number | 5-6 |
| DOIs | |
| State | Published - 1 Jan 1976 |
| Externally published | Yes |
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Developmental Biology