Hierarchically Assembled Two-dimensional Hybrid Nanointerfaces: A Platform for Bioelectronic Applications

Renu Kumari; Adeniyi Olugbenga Osikoya; William Wilson Anku; Sudheesh Kumar Shukla; Penny Poomani Govender

doi:10.1002/elan.201800338

Hierarchically Assembled Two-dimensional Hybrid Nanointerfaces: A Platform for Bioelectronic Applications

Renu Kumari
, Adeniyi Olugbenga Osikoya
, William Wilson Anku
, Sudheesh Kumar Shukla
, Penny Poomani Govender

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

We introduce a hybrid two-dimensional nanointerface structure for bioelectronic systems. We fabricated smart hierarchically self-assembled 2D electrobiocatalytic interface system based on the combination of gold nanoparticles doped graphene oxide (GO)-molybdenum disulfide (MoS₂) layered nanohybrid, conjugated with poly (N-isopropylacrylamide, PNIPAAm) resulting in GO/AuNPs/MoS₂/PNIPAAm interface. Horseradish peroxidase (HRP) was subsequently immobilized on the GO/AuNPs/MoS₂/PNIPAAm interface through electrostatic interactions giving GO/AuNPs/MoS₂/PNIPAAm/Peroxidase electrobiocatalytic interface system as a platform for electrobiocatalysis reactions for biosensing and bioelectronic applications. The electrobiocatalytic activity of the nanohybrid interface structure was studied using hydrogen peroxide (H₂O₂) as a model analyte. Cyclic Voltammetry showed diffusion controlled electron transfer properties at the interface. The fabricated bioelectrode exhibits a wide linear response to the detection of H₂O₂ from 1.57 to 11.33 mM, with a detection limit of 3.34 mM (S/N=3) and a capacitance of 8.6 F/cm².

Original language	English
Pages (from-to)	2339-2348
Number of pages	10
Journal	Electroanalysis
Volume	30
Issue number	10
DOIs	https://doi.org/10.1002/elan.201800338
State	Published - 1 Oct 2018
Externally published	Yes

Keywords

bioelectronics
biosensors
MoS
Nanohybrid interface
two-dimensional (2D) nanointerfaces

ASJC Scopus subject areas

Analytical Chemistry
Electrochemistry

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10.1002/elan.201800338

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@article{5149e31d0303420189d03f154fbef849,

title = "Hierarchically Assembled Two-dimensional Hybrid Nanointerfaces: A Platform for Bioelectronic Applications",

abstract = "We introduce a hybrid two-dimensional nanointerface structure for bioelectronic systems. We fabricated smart hierarchically self-assembled 2D electrobiocatalytic interface system based on the combination of gold nanoparticles doped graphene oxide (GO)-molybdenum disulfide (MoS2) layered nanohybrid, conjugated with poly (N-isopropylacrylamide, PNIPAAm) resulting in GO/AuNPs/MoS2/PNIPAAm interface. Horseradish peroxidase (HRP) was subsequently immobilized on the GO/AuNPs/MoS2/PNIPAAm interface through electrostatic interactions giving GO/AuNPs/MoS2/PNIPAAm/Peroxidase electrobiocatalytic interface system as a platform for electrobiocatalysis reactions for biosensing and bioelectronic applications. The electrobiocatalytic activity of the nanohybrid interface structure was studied using hydrogen peroxide (H2O2) as a model analyte. Cyclic Voltammetry showed diffusion controlled electron transfer properties at the interface. The fabricated bioelectrode exhibits a wide linear response to the detection of H2O2 from 1.57 to 11.33 mM, with a detection limit of 3.34 mM (S/N=3) and a capacitance of 8.6 F/cm2.",

keywords = "bioelectronics, biosensors, MoS, Nanohybrid interface, two-dimensional (2D) nanointerfaces",

author = "Renu Kumari and Osikoya, \{Adeniyi Olugbenga\} and Anku, \{William Wilson\} and Shukla, \{Sudheesh Kumar\} and Govender, \{Penny Poomani\}",

note = "Publisher Copyright: {\textcopyright} 2018 Wiley-VCH Verlag GmbH \& Co. KGaA, Weinheim",

year = "2018",

month = oct,

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doi = "10.1002/elan.201800338",

language = "English",

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journal = "Electroanalysis",

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TY - JOUR

T1 - Hierarchically Assembled Two-dimensional Hybrid Nanointerfaces

T2 - A Platform for Bioelectronic Applications

AU - Kumari, Renu

AU - Osikoya, Adeniyi Olugbenga

AU - Anku, William Wilson

AU - Shukla, Sudheesh Kumar

AU - Govender, Penny Poomani

PY - 2018/10/1

Y1 - 2018/10/1

N2 - We introduce a hybrid two-dimensional nanointerface structure for bioelectronic systems. We fabricated smart hierarchically self-assembled 2D electrobiocatalytic interface system based on the combination of gold nanoparticles doped graphene oxide (GO)-molybdenum disulfide (MoS2) layered nanohybrid, conjugated with poly (N-isopropylacrylamide, PNIPAAm) resulting in GO/AuNPs/MoS2/PNIPAAm interface. Horseradish peroxidase (HRP) was subsequently immobilized on the GO/AuNPs/MoS2/PNIPAAm interface through electrostatic interactions giving GO/AuNPs/MoS2/PNIPAAm/Peroxidase electrobiocatalytic interface system as a platform for electrobiocatalysis reactions for biosensing and bioelectronic applications. The electrobiocatalytic activity of the nanohybrid interface structure was studied using hydrogen peroxide (H2O2) as a model analyte. Cyclic Voltammetry showed diffusion controlled electron transfer properties at the interface. The fabricated bioelectrode exhibits a wide linear response to the detection of H2O2 from 1.57 to 11.33 mM, with a detection limit of 3.34 mM (S/N=3) and a capacitance of 8.6 F/cm2.

AB - We introduce a hybrid two-dimensional nanointerface structure for bioelectronic systems. We fabricated smart hierarchically self-assembled 2D electrobiocatalytic interface system based on the combination of gold nanoparticles doped graphene oxide (GO)-molybdenum disulfide (MoS2) layered nanohybrid, conjugated with poly (N-isopropylacrylamide, PNIPAAm) resulting in GO/AuNPs/MoS2/PNIPAAm interface. Horseradish peroxidase (HRP) was subsequently immobilized on the GO/AuNPs/MoS2/PNIPAAm interface through electrostatic interactions giving GO/AuNPs/MoS2/PNIPAAm/Peroxidase electrobiocatalytic interface system as a platform for electrobiocatalysis reactions for biosensing and bioelectronic applications. The electrobiocatalytic activity of the nanohybrid interface structure was studied using hydrogen peroxide (H2O2) as a model analyte. Cyclic Voltammetry showed diffusion controlled electron transfer properties at the interface. The fabricated bioelectrode exhibits a wide linear response to the detection of H2O2 from 1.57 to 11.33 mM, with a detection limit of 3.34 mM (S/N=3) and a capacitance of 8.6 F/cm2.

KW - bioelectronics

KW - biosensors

KW - MoS

KW - Nanohybrid interface

KW - two-dimensional (2D) nanointerfaces

UR - https://www.scopus.com/pages/publications/85050641887

U2 - 10.1002/elan.201800338

DO - 10.1002/elan.201800338

M3 - Article

AN - SCOPUS:85050641887

SN - 1040-0397

VL - 30

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JO - Electroanalysis

JF - Electroanalysis

IS - 10

ER -

Hierarchically Assembled Two-dimensional Hybrid Nanointerfaces: A Platform for Bioelectronic Applications

Abstract

Keywords

ASJC Scopus subject areas

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