High affinity heparin detection by multivalent supramolecular polymers through aggregation induced emission

Shubhra Kanti Bhaumik, Yoti Shankar Patra, Supratim Banerjee

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Amphiphilic di-cationic cyanostilbene derivatives with aggregation induced emission (AIE) features formed luminescent supramolecular polymers in aqueous media. They bind bio-polyanion heparin, a known anticoagulant, in a multivalent fashion through the formation of co-assemblies with highly enhanced greenish-yellow emission. Heparin detection in nanomolar concentrations in buffer and in medically relevant concentrations in human serum and plasma was achieved.

Original languageEnglish
Pages (from-to)9541-9544
Number of pages4
JournalChemical Communications
Volume56
Issue number66
DOIs
StatePublished - 25 Aug 2020
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • General Chemistry
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Fingerprint

Dive into the research topics of 'High affinity heparin detection by multivalent supramolecular polymers through aggregation induced emission'. Together they form a unique fingerprint.

Cite this