High cancer detection rate using cognitive fusion - targeted transperineal prostate biopsies

Snir Dekalo, Haim Matzkin, Nicola J. Mabjeesh

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Objective MRI of the prostate improves diagnostic accuracy of prostate cancer. Different fusion approaches with transrectal ultrasound images are employed. Objective: To determine detection rate of prostate cancer in men undergoing transperineal MRIbased cognitive fusion biopsy. Materials and Methods: One hundred and sixty-four consecutive men underwent a multiple-core prostate transperineal biopsy. Univariable and multivariable logistic regression analyses were used to address the relationship between clinical parameters and prostate cancer detection rate. Results: One hundred and fourteen patients underwent mpMRI prior to the transperineal biopsy, 52 (45%) were diagnosed with prostate cancer, of them, 36 had Gleason score ≥7 (69%). Among these 114 patients, 82 had suspicious lesions on MRI, and 43 of them were diagnosed with cancer (52%). On multivariate analysis, the most significant independent predictive factors were PSA density (P < 0.001) and suspicious MRI lesion (P=0.006). Men with a PSA density of more than 0.22 and a suspicious lesion on MRI had a detection rate of 78%. Detection rate among 50 patients with no MRI study prior to this biopsy was 26%. Conclusions: This study showed that among a group of mostly multi-biopsied patients, the presence of mpMRI lesions and high PSA density values helped to detect clinically significant prostate cancer using cognitive MRI/TRUS fusion biopsies.

Original languageEnglish
Pages (from-to)600-606
Number of pages7
JournalInternational braz j urol : official journal of the Brazilian Society of Urology
Volume43
Issue number4
DOIs
StatePublished - 1 Jul 2017
Externally publishedYes

Keywords

  • Biopsy
  • Magnetic resonance imaging
  • Prostatic neoplasms

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