High-dose chemotherapy: Therapeutic potential in the age of growth factor support

S. Ariad, W. R. Bezwoda

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

The steep dose-response curve for most chemotherapeutic drugs and the need to overcome tumor resistance has resulted in renewed interest in the use of high-dose chemotherapy. Bone marrow rescue has allowed the dose-limiting barrier of hematopoietic suspension to be overcome. However, despite such salvage methods and the use of blood products and effective antibiotics, myelosuppression remains a major obstacle to treatment. The use of recombinant colony-stimulating factors in combination with bone marrow following high-dose chemotherapy may well shorten the period of neutropenia and reduce the frequency of neutropenia-related complications, thus making high-dose treatment more acceptable.

Original languageEnglish
Pages (from-to)377-385
Number of pages9
JournalIsrael Journal of Medical Sciences
Volume28
Issue number6
StatePublished - 1 Jan 1992
Externally publishedYes

Keywords

  • Autologous bone marrow transplantation
  • Bone marrow rescue
  • Colony-stimulating factors
  • High-dose chemotherapy

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