Abstract
Concentrations of Fraction I and II endorphins in CSF and serum and CSF haloperidol levels were determined in 12 patients with therapy-resistant chronic schizophrenia during high-dose haloperidol medication. After increasing the haloperidol dose from 60 mg to 120 mg daily a tendency for an increase of CSF Fraction I endorphin level was observed (t = 1.65 p > 0.05). In addition, there was a trend for a parallel increase of CSF Fraction I endorphin and serum and CSF haloperidol levels although the correlations did not reach statistical significance.
| Original language | English |
|---|---|
| Pages (from-to) | 9-12 |
| Number of pages | 4 |
| Journal | Pharmacopsychiatria |
| Volume | 6 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1 Jan 1983 |
| Externally published | Yes |
ASJC Scopus subject areas
- General Medicine