High-dose peripheral inositol raises brain inositol levels and reverses behavioral effects of inositol depletion by lithium

Galila Agam, Yoseph Shapiro, Yuly Bersudsky, Ora Kofman, R. H. Belmaker

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

Lithium (Li) reduces brain inositol levels. Berridge has suggested that this effect is related to Li's mechanism of action. It had previously been shown that pilocarpine causes a limbic seizure syndrome in lithium treated rats, and that these lithium-pilocarpine seizures are reversible by intracerebroventricular inositol administration to rats. We now show that although inositol passes the blood-brain barrier poorly, large doses of intraperitoneal (IP) inositol can also reverse Li-pilocarpine seizures. Using gas chromatography, IP inositol can raise brain inositol levels. Demonstration that inositol enters brain after peripheral administration provides a basis for possible pharmacological intervention in psychiatric disorders at the level of second messengers linked to the phosphatidylinositol cycle.

Original languageEnglish
Pages (from-to)341-343
Number of pages3
JournalPharmacology Biochemistry and Behavior
Volume49
Issue number2
DOIs
StatePublished - 1 Jan 1994

Keywords

  • Blood-brain barrier
  • Inositol
  • Li-pilocarpine seizures
  • Lithium

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