High normal uric acid levels are associated with an increased risk of diabetes in lean, normoglycemic healthy women

Michal Shani, Shlomo Vinker, Dganit Dinour, Merav Leiba, Gilad Twig, Eliezer J. Holtzman, Adi Leiba

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


Context: The risk associated with serum uric acid (SUA) levels within the normal range is unknown, especially among lean and apparently healthy adults. Objective: Evaluating whether high-normal SUA levels, 6.8 mg/dL and below, are associated with an increased diabetes risk, compared with low-normal SUA. Design and Setting: This was a cohort study with 10 years of followup involving all clinics of the largest nationally distributed Health Maintenance Organization in Israel. Participants: Participants included 469,947 examinees, 40-70 years old at baseline, who had their SUA measured during 2002. We excluded examinees who had hyperuricemia (SUA > 6.8 mg/dL), impaired fasting glucose, overweight or obesity and chronic cardiovascular or renal disorders. The final cohort was composed of 30 302 participants. Interventions: Participants were followed up to a new diagnosis of diabetes during the study period. Main Outcome Measures: Odds ratio of developing diabetes among participants with high-normal baseline SUA were compared with low-normal (2 > uric acid = 3 and 3 > uric acid = 4 in women and men, respectively). Results: In a logistic regression model adjusted for age, body mass index, socioeconomic status, smoking, baseline estimated glomerular filtration rate, and baseline glucose, SUA levels of 4-5 mg/dL for women were associated with 61% increased risk for incident diabetes (95% confidence interval, 1.1-2.3). At the highest normal levels for women (SUA, 5-6 mg/dL) the odds ratio was 2.7 (1.8-4.0), whereas men had comparable diabetes risk at values of 6-6.8 mg/dL (hazard ratio, 1.35; 95% confidence interval, 0.9-2.1). Conclusions: SUA levels within the normal range are associated with an increased risk for newonset diabetes among healthy lean women when compared with those with low-normal values.

Original languageEnglish
Pages (from-to)3772-3778
Number of pages7
JournalJournal of Clinical Endocrinology and Metabolism
Issue number10
StatePublished - 1 Oct 2016
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical


Dive into the research topics of 'High normal uric acid levels are associated with an increased risk of diabetes in lean, normoglycemic healthy women'. Together they form a unique fingerprint.

Cite this