High prevalence of genetically diverse Borrelia bavariensis-like strains in Ixodes persulcatus from Selenge Aimag, Mongolia

Holger C. Scholz; G. Margos; H. Derschum; S. Speck; D. Tserennorov; N. Erdenebat; B. Undraa; M. Enkhtuja; J. Battsetseg; C. Otgonchimeg; G. Otgonsuren; B. Nymadulam; A. Römer; A. Thomas; S. Essbauer; R. Wölfel; D. Kiefer; L. Zöller; D. Otgonbaatar; V. Fingerle

doi:10.1016/j.ttbdis.2012.08.004

High prevalence of genetically diverse Borrelia bavariensis-like strains in Ixodes persulcatus from Selenge Aimag, Mongolia

Holger C. Scholz, G. Margos, H. Derschum, S. Speck, D. Tserennorov, N. Erdenebat, B. Undraa, M. Enkhtuja, J. Battsetseg, C. Otgonchimeg, G. Otgonsuren, B. Nymadulam, A. Römer, A. Thomas, S. Essbauer, R. Wölfel, D. Kiefer, L. Zöller, D. Otgonbaatar, V. Fingerle

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

In Mongolia, Lyme borreliosis was first reported in 2003. To determine which Borrelia species may contribute to the occurrence of Lyme borreliosis in Mongolia, real-time PCR was conducted on 372 adult Ixodes persulcatus ticks collected in Selenge Aimag, the province with the highest incidence of human Lyme borreliosis. 24.5% of ticks were identified to be positive for Borrelia burgdorferi sensu lato DNA. Species differentiation using an SNP-based real-time PCR and multi-locus sequence analysis revealed that strains phylogenetically closely related to B. bavariensis (previously known as B. garinii OspA serotype 4) is the most prevalent species, showing an unexpectedly high genetic diversity.

Original language	English
Pages (from-to)	89-92
Number of pages	4
Journal	Ticks and Tick-borne Diseases
Volume	4
Issue number	1-2
DOIs	https://doi.org/10.1016/j.ttbdis.2012.08.004
State	Published - 1 Feb 2013
Externally published	Yes

Keywords

Borrelia
Genetic diversity
Ixodes persulcatus
Molecular ecology
Real-time PCR
Selenge Aimag
Subtyping

ASJC Scopus subject areas

Parasitology
Microbiology
Insect Science
Infectious Diseases

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Scholz, H. C., Margos, G., Derschum, H., Speck, S., Tserennorov, D., Erdenebat, N., Undraa, B., Enkhtuja, M., Battsetseg, J., Otgonchimeg, C., Otgonsuren, G., Nymadulam, B., Römer, A., Thomas, A., Essbauer, S., Wölfel, R., Kiefer, D., Zöller, L., Otgonbaatar, D., & Fingerle, V. (2013). High prevalence of genetically diverse Borrelia bavariensis-like strains in Ixodes persulcatus from Selenge Aimag, Mongolia. Ticks and Tick-borne Diseases, 4(1-2), 89-92. https://doi.org/10.1016/j.ttbdis.2012.08.004

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title = "High prevalence of genetically diverse Borrelia bavariensis-like strains in Ixodes persulcatus from Selenge Aimag, Mongolia",

abstract = "In Mongolia, Lyme borreliosis was first reported in 2003. To determine which Borrelia species may contribute to the occurrence of Lyme borreliosis in Mongolia, real-time PCR was conducted on 372 adult Ixodes persulcatus ticks collected in Selenge Aimag, the province with the highest incidence of human Lyme borreliosis. 24.5% of ticks were identified to be positive for Borrelia burgdorferi sensu lato DNA. Species differentiation using an SNP-based real-time PCR and multi-locus sequence analysis revealed that strains phylogenetically closely related to B. bavariensis (previously known as B. garinii OspA serotype 4) is the most prevalent species, showing an unexpectedly high genetic diversity.",

keywords = "Borrelia, Genetic diversity, Ixodes persulcatus, Molecular ecology, Real-time PCR, Selenge Aimag, Subtyping",

author = "Scholz, {Holger C.} and G. Margos and H. Derschum and S. Speck and D. Tserennorov and N. Erdenebat and B. Undraa and M. Enkhtuja and J. Battsetseg and C. Otgonchimeg and G. Otgonsuren and B. Nymadulam and A. R{\"o}mer and A. Thomas and S. Essbauer and R. W{\"o}lfel and D. Kiefer and L. Z{\"o}ller and D. Otgonbaatar and V. Fingerle",

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doi = "10.1016/j.ttbdis.2012.08.004",

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Scholz, HC, Margos, G, Derschum, H, Speck, S, Tserennorov, D, Erdenebat, N, Undraa, B, Enkhtuja, M, Battsetseg, J, Otgonchimeg, C, Otgonsuren, G, Nymadulam, B, Römer, A, Thomas, A, Essbauer, S, Wölfel, R, Kiefer, D, Zöller, L, Otgonbaatar, D & Fingerle, V 2013, 'High prevalence of genetically diverse Borrelia bavariensis-like strains in Ixodes persulcatus from Selenge Aimag, Mongolia', Ticks and Tick-borne Diseases, vol. 4, no. 1-2, pp. 89-92. https://doi.org/10.1016/j.ttbdis.2012.08.004

TY - JOUR

T1 - High prevalence of genetically diverse Borrelia bavariensis-like strains in Ixodes persulcatus from Selenge Aimag, Mongolia

AU - Scholz, Holger C.

AU - Margos, G.

AU - Derschum, H.

AU - Speck, S.

AU - Tserennorov, D.

AU - Erdenebat, N.

AU - Undraa, B.

AU - Enkhtuja, M.

AU - Battsetseg, J.

AU - Otgonchimeg, C.

AU - Otgonsuren, G.

AU - Nymadulam, B.

AU - Römer, A.

AU - Thomas, A.

AU - Essbauer, S.

AU - Wölfel, R.

AU - Kiefer, D.

AU - Zöller, L.

AU - Otgonbaatar, D.

AU - Fingerle, V.

PY - 2013/2/1

Y1 - 2013/2/1

N2 - In Mongolia, Lyme borreliosis was first reported in 2003. To determine which Borrelia species may contribute to the occurrence of Lyme borreliosis in Mongolia, real-time PCR was conducted on 372 adult Ixodes persulcatus ticks collected in Selenge Aimag, the province with the highest incidence of human Lyme borreliosis. 24.5% of ticks were identified to be positive for Borrelia burgdorferi sensu lato DNA. Species differentiation using an SNP-based real-time PCR and multi-locus sequence analysis revealed that strains phylogenetically closely related to B. bavariensis (previously known as B. garinii OspA serotype 4) is the most prevalent species, showing an unexpectedly high genetic diversity.

AB - In Mongolia, Lyme borreliosis was first reported in 2003. To determine which Borrelia species may contribute to the occurrence of Lyme borreliosis in Mongolia, real-time PCR was conducted on 372 adult Ixodes persulcatus ticks collected in Selenge Aimag, the province with the highest incidence of human Lyme borreliosis. 24.5% of ticks were identified to be positive for Borrelia burgdorferi sensu lato DNA. Species differentiation using an SNP-based real-time PCR and multi-locus sequence analysis revealed that strains phylogenetically closely related to B. bavariensis (previously known as B. garinii OspA serotype 4) is the most prevalent species, showing an unexpectedly high genetic diversity.

KW - Borrelia

KW - Genetic diversity

KW - Ixodes persulcatus

KW - Molecular ecology

KW - Real-time PCR

KW - Selenge Aimag

KW - Subtyping

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AN - SCOPUS:84872613524

SN - 1877-959X

VL - 4

SP - 89

EP - 92

JO - Ticks and Tick-borne Diseases

JF - Ticks and Tick-borne Diseases

IS - 1-2

ER -

High prevalence of genetically diverse Borrelia bavariensis-like strains in Ixodes persulcatus from Selenge Aimag, Mongolia

Abstract

Keywords

ASJC Scopus subject areas

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