High proportions of dementia among SLE patients: A big data analysis

Omer Gendelman, Shmuel Tiosano, Yehuda Shoenfeld, Doron Comaneshter, Howard Amital, Arnon D. Cohen, Daniela Amital

    Research output: Contribution to journalArticlepeer-review

    13 Scopus citations

    Abstract

    Objective: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease affecting a wide range of systems including the peripheral and central nervous system. Cognitive impairment leading to dementia is one of the harmful central nervous system afflictions of SLE. The aim of this study was to investigate the association of SLE with dementia. Methods: A cross-sectional study was conducted using Clalit Health Care database, the largest health maintenance organization in Israel with more than 4.4 million enrollees. Systemic lupus erythematosus patients were compared in a 1:5 ratio to age- and sex-matched controls. Chi-square and t tests were used for univariate analysis, and a logistic regression model was used for multivariate analysis. Results: The study included 4886 SLE patients and 24 430 age-frequency- and sex-frequency-matched controls without SLE. The proportion of dementia was higher among SLE patients compared to controls (1.56% and 0.51%, respectively; P <.001). This finding was consistent across all age groups by univariate analysis. In a multivariate logistic regression analysis, SLE was significantly associated with dementia (odds ratio = 1.51, 95% confidence interval, 1.11-2.04). Conclusion: Systemic lupus erythematosus is significantly associated with dementia. This finding should give rise to search for SLE in patients with an ambiguous cause for dementia, especially those with an early onset cognitive decline.

    Original languageEnglish
    Pages (from-to)531-536
    Number of pages6
    JournalInternational Journal of Geriatric Psychiatry
    Volume33
    Issue number3
    DOIs
    StatePublished - 1 Mar 2018

    Keywords

    • age
    • autoimmunity
    • cerebrovascular disease
    • dementia
    • risk factors
    • systemic lupus erythematosus

    ASJC Scopus subject areas

    • Geriatrics and Gerontology
    • Psychiatry and Mental health

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