@article{e3a6e93d58574636ac844f607f7e06ed,
title = "Higher CSF sTNFR1-related proteins associate with better prognosis in very early Alzheimer{\textquoteright}s disease",
abstract = "Neuroinflammation is associated with Alzheimer{\textquoteright}s disease, but the application of cerebrospinal fluid measures of inflammatory proteins may be limited by overlapping pathways and relationships between them. In this work, we measure 15 cerebrospinal proteins related to microglial and T-cell functions, and show them to reproducibly form functionally-related groups within and across diagnostic categories in 382 participants from the Alzheimer{\textquoteright}s Disease Neuro-imaging Initiative as well participants from two independent cohorts. We further show higher levels of proteins related to soluble tumor necrosis factor receptor 1 are associated with reduced risk of conversion to dementia in the multi-centered (p = 0.027) and independent (p = 0.038) cohorts of people with mild cognitive impairment due to predicted Alzheimer{\textquoteright}s disease, while higher soluble TREM2 levels associated with slower decline in the dementia stage of Alzheimer{\textquoteright}s disease. These inflammatory proteins thus provide prognostic information independent of established Alzheimer{\textquoteright}s markers.",
author = "{Alzheimer{\textquoteright}s Disease Neuroimaging Initiative} and Hu, {William T.} and Tugba Ozturk and Alexander Kollhoff and Whitney Wharton and {Christina Howell}, J. and Michael Weiner and Paul Aisen and Ronald Petersen and Jack, {Clifford R.} and William Jagust and Trojanowki, {John Q.} and Toga, {Arthur W.} and Laurel Beckett and Green, {Robert C.} and Saykin, {Andrew J.} and John Morris and Perrin, {Richard J.} and Shaw, {Leslie M.} and Zaven Kachaturian and Maria Carrillo and William Potter and Lisa Barnes and Marie Bernard and Hector Gonz{\'a}lez and Carole Ho and Hsiao, {John K.} and Eliezer Masliah and Donna Masterman and Ozioma Okonkwo and Laurie Ryan and Nina Silverberg and Adam Fleisher and Tom Montine and Kaye, {Jeffrey A.} and Silbert, {Lisa C.} and Schneider, {Lon S.} and Sonia Pawluczyk and Mauricio Becerra and James Brewer and Heidebrink, {Judith L.} and David Knopman and Javier Villanueva-Meyer and Doody, {Rachelle S.} and Kass, {Joseph S.} and Yaakov Stern and Honig, {Lawrence S.} and Akiva Mintz and Beau Ances and Mintun, {Mark A.} and Irina Rachinsky",
note = "Publisher Copyright: {\textcopyright} 2021, The Author(s).",
year = "2021",
month = dec,
day = "1",
doi = "10.1038/s41467-021-24220-7",
language = "English",
volume = "12",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
number = "1",
}
