Highly efficient and chemoselective peptide ubiquitylation

K. S. Ajish Kumar, Mahmood Haj-Yahya, Diana Olschewski, Hilal A. Lashuel, Ashraf Brik

Research output: Contribution to journalArticlepeer-review

209 Scopus citations

Abstract

Loving kiss of death: A highly efficient and chemoselective method for ubiquitylation of peptides using δ-mercaptolysine to assist isopeptide formation between the ε-NH2 of the lysine residue and the activated C-terminal glycine of ubiquitin (Ub) is presented.

Original languageEnglish
Pages (from-to)8090-8094
Number of pages5
JournalAngewandte Chemie - International Edition
Volume48
Issue number43
DOIs
StatePublished - 12 Oct 2009

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry

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