Highly sensitive detection of paclitaxel by surface-enhanced Raman scattering

Maximilien Cottat, Nathalie Lidgi-Guigui, Frédéric Hamouda, Bernard Bartenlian, Divya Venkataraman, Robert S. Marks, Terry W.J. Steele, Marc Lamy De La Chapelle

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


The surface-enhanced Raman scattering (SERS) technique was shown to be an effective molecular analytical tool due to its high sensitivity. Here, we propose to exploit soft UV assisted nanoimprint lithography (UV-NIL) for the development of a reproducible and highly-sensitive SERS biosensor. Soft lithography is known to be advantageous for biological applications since it is compatible with insulating supports and large-area samples. In the present investigations, soft UV-NIL is used for the fabrication of large-sized arrays of gold nanocylinders on glass which were shown to be highly sensitive and highly specific sensing surfaces, with a limit of detection measured down to 1 nM. Employing the UV-NIL SERS substrate enable working ranges of nanomolar to micromolar concentrations in regards to our model paclitaxel analyte.

Original languageEnglish
Article number114019
JournalJournal of Optics (United Kingdom)
Issue number11
StatePublished - 23 Oct 2015


  • SERS
  • biosensors
  • nanoimprint
  • paclitaxel
  • soft UV-NIL

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics


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