Highly stable pleated-sheet secondary structure in assemblies of amphiphilic α/β-peptides at the air-water interface

Shlomit Segman; Myung Ryul Lee; Vladimir Vaiser; Samuel H. Gellman; Hanna Rapaport

doi:10.1002/anie.200904566

Highly stable pleated-sheet secondary structure in assemblies of amphiphilic α/β-peptides at the air-water interface

Shlomit Segman, Myung Ryul Lee, Vladimir Vaiser, Samuel H. Gellman, Hanna Rapaport

Department of Biotechnology Engineering

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

(Figure Presented) A nice gathering at the interface: The de novo design and characterization of amphiphilic α/β-peptides, which form ordered two-dimensional assemblies at the air-water interface composed of olig-omers in pleated conformation similar to β-sheets of a-peptides, is reported. The positioning of ionic side chains along the backbone can exert a profound effect on the propensity to self-assemble.

Original language	English
Pages (from-to)	716-719
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	49
Issue number	4
DOIs	https://doi.org/10.1002/anie.200904566
State	Published - 18 Jan 2010

Keywords

Foldamers
Monolayers
Peptides
Self-assembly
β-sheet

ASJC Scopus subject areas

Catalysis
General Chemistry

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10.1002/anie.200904566

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AU - Vaiser, Vladimir

AU - Gellman, Samuel H.

AU - Rapaport, Hanna

PY - 2010/1/18

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AB - (Figure Presented) A nice gathering at the interface: The de novo design and characterization of amphiphilic α/β-peptides, which form ordered two-dimensional assemblies at the air-water interface composed of olig-omers in pleated conformation similar to β-sheets of a-peptides, is reported. The positioning of ionic side chains along the backbone can exert a profound effect on the propensity to self-assemble.

KW - Foldamers

KW - Monolayers

KW - Peptides

KW - Self-assembly

KW - β-sheet

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Highly stable pleated-sheet secondary structure in assemblies of amphiphilic α/β-peptides at the air-water interface

Abstract

Keywords

ASJC Scopus subject areas

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