Histological and chemical analyses of mesiodens development and mineralization

Awady Muhamad, Moskovitz Moti, Cohen Ornit, Zilberman Uri

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Objective This study aimed to compare the developmental timing and mineralization quality of mesiodentes, i.e., supernumerary teeth located mainly in the midline of the maxilla between the central incisors, with the developmental timing and mineralization quality of permanent and primary central incisors. Design Sixteen mesiodentes, nine permanent and seven primary central incisors were collected. The location of the neonatal line was determined using a light microscope at 10× or 20× enlargements. Chemical composition of the enamel at two locations was analyzed using energy dispersive X-ray spectrometer. Results Neonatal lines were observed in eight out of 16 mesiodentes, in all primary central incisors and in none of the permanent central incisors. Chemical analyses showed that mesiodentes mineralization was impaired, resulting in higher amount of organic ions and reduced inorganic ions. Discriminant analysis showed minimal overlap of mesiodentes with either primary or permanent centrals. Conclusions Mesiodentes development begins before birth in 50% of the cases but later than the primary centrals. Mineralization of mesiodens is impaired with less mineral content and higher organic content. The results showed that mesiodentes are a special group of teeth with defective morpho-differentiation and mineralization, with little similarity to primary or permanent central incisors.

Original languageEnglish
Pages (from-to)191-195
Number of pages5
JournalArchives of Oral Biology
StatePublished - 1 Mar 2018
Externally publishedYes


  • Chemical analysis
  • Enamel
  • Mesiodentes
  • Supernumerary teeth

ASJC Scopus subject areas

  • Otorhinolaryngology
  • General Dentistry
  • Cell Biology


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