Histone Mono-Ubiquitination in Transcriptional Regulation and Its Mark on Life: Emerging Roles in Tissue Development and Disease

Liat Oss-Ronen; Tzlil Sarusi; Idan Cohen

doi:10.3390/cells11152404

Histone Mono-Ubiquitination in Transcriptional Regulation and Its Mark on Life: Emerging Roles in Tissue Development and Disease

Liat Oss-Ronen, Tzlil Sarusi, Idan Cohen

The Shraga Segal Department of Microbiology and Immunology

Research output: Contribution to journal › Review article › peer-review

21 Scopus citations

Abstract

Epigenetic regulation plays an essential role in driving precise transcriptional programs during development and homeostasis. Among epigenetic mechanisms, histone mono-ubiquitination has emerged as an important post-transcriptional modification. Two major histone mono-ubiquitination events are the mono-ubiquitination of histone H2A at lysine 119 (H2AK119ub), placed by Polycomb repressive complex 1 (PRC1), and histone H2B lysine 120 mono-ubiquitination (H2BK120ub), placed by the heteromeric RNF20/RNF40 complex. Both of these events play fundamental roles in shaping the chromatin epigenetic landscape and cellular identity. In this review we summarize the current understandings of molecular concepts behind histone mono-ubiquitination, focusing on their recently identified roles in tissue development and pathologies.

Original language	English
Article number	2404
Journal	Cells
Volume	11
Issue number	15
DOIs	https://doi.org/10.3390/cells11152404
State	Published - 1 Aug 2022

Keywords

H2AK119ub
H2BK120ub
Polycomb repressive complex 1
RNF20
RNF40
cancer
development
elongation
histones
mono-ubiquitination
repression
transcription

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/cells11152404

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title = "Histone Mono-Ubiquitination in Transcriptional Regulation and Its Mark on Life: Emerging Roles in Tissue Development and Disease",

abstract = "Epigenetic regulation plays an essential role in driving precise transcriptional programs during development and homeostasis. Among epigenetic mechanisms, histone mono-ubiquitination has emerged as an important post-transcriptional modification. Two major histone mono-ubiquitination events are the mono-ubiquitination of histone H2A at lysine 119 (H2AK119ub), placed by Polycomb repressive complex 1 (PRC1), and histone H2B lysine 120 mono-ubiquitination (H2BK120ub), placed by the heteromeric RNF20/RNF40 complex. Both of these events play fundamental roles in shaping the chromatin epigenetic landscape and cellular identity. In this review we summarize the current understandings of molecular concepts behind histone mono-ubiquitination, focusing on their recently identified roles in tissue development and pathologies.",

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author = "Liat Oss-Ronen and Tzlil Sarusi and Idan Cohen",

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T2 - Emerging Roles in Tissue Development and Disease

AU - Oss-Ronen, Liat

AU - Sarusi, Tzlil

AU - Cohen, Idan

PY - 2022/8/1

Y1 - 2022/8/1

N2 - Epigenetic regulation plays an essential role in driving precise transcriptional programs during development and homeostasis. Among epigenetic mechanisms, histone mono-ubiquitination has emerged as an important post-transcriptional modification. Two major histone mono-ubiquitination events are the mono-ubiquitination of histone H2A at lysine 119 (H2AK119ub), placed by Polycomb repressive complex 1 (PRC1), and histone H2B lysine 120 mono-ubiquitination (H2BK120ub), placed by the heteromeric RNF20/RNF40 complex. Both of these events play fundamental roles in shaping the chromatin epigenetic landscape and cellular identity. In this review we summarize the current understandings of molecular concepts behind histone mono-ubiquitination, focusing on their recently identified roles in tissue development and pathologies.

AB - Epigenetic regulation plays an essential role in driving precise transcriptional programs during development and homeostasis. Among epigenetic mechanisms, histone mono-ubiquitination has emerged as an important post-transcriptional modification. Two major histone mono-ubiquitination events are the mono-ubiquitination of histone H2A at lysine 119 (H2AK119ub), placed by Polycomb repressive complex 1 (PRC1), and histone H2B lysine 120 mono-ubiquitination (H2BK120ub), placed by the heteromeric RNF20/RNF40 complex. Both of these events play fundamental roles in shaping the chromatin epigenetic landscape and cellular identity. In this review we summarize the current understandings of molecular concepts behind histone mono-ubiquitination, focusing on their recently identified roles in tissue development and pathologies.

KW - H2AK119ub

KW - H2BK120ub

KW - Polycomb repressive complex 1

KW - RNF20

KW - RNF40

KW - cancer

KW - development

KW - elongation

KW - histones

KW - mono-ubiquitination

KW - repression

KW - transcription

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U2 - 10.3390/cells11152404

DO - 10.3390/cells11152404

M3 - Review article

C2 - 35954248

AN - SCOPUS:85136341221

SN - 2073-4409

VL - 11

JO - Cells

JF - Cells

IS - 15

M1 - 2404

ER -

Histone Mono-Ubiquitination in Transcriptional Regulation and Its Mark on Life: Emerging Roles in Tissue Development and Disease

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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