History of clozapine

Chanoch Miodownik, Alexander Grinshpoon, Vladimir Lerner

    Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


    The history of the discovery and introduction of clozapine in clinical practice is very unusual and complex in comparison to other antipsychotics. In this chapter we review the complicated path from discovery through abrupt discontinuation of use and successful comeback as a unique treatment for patients with treatment resistant schizophrenia.

    Original languageEnglish
    Title of host publicationClozapine
    Subtitle of host publicationMedical Uses, Interactions and Side Effects
    PublisherNova Science Publishers, Inc.
    Number of pages13
    ISBN (Electronic)9781536169928
    StatePublished - 1 Jan 2020


    • Antipsychotics
    • Clozapine
    • Plasticity
    • Schizophrenia
    • Treatment

    ASJC Scopus subject areas

    • Medicine (all)
    • Pharmacology, Toxicology and Pharmaceutics (all)


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