HIV-1 protease: Mechanism and drug discovery

Ashraf Brik, Chi Huey Wong

Research output: Contribution to journalArticlepeer-review

392 Scopus citations


The identification of the HIV retrovirus and the accumulated knowledge about the role of the different elements in its life cycle led researchers around the world to develop inhibitors that target different steps in the life cycle of the virus. One of the targets is HIV-1 protease (HIV PR), an essential enzyme needed in the proper assembly and maturation of infectious virions. Understanding the chemical mechanism of this enzyme has been a basic requirement in the development of efficient inhibitors. This review summarizes studies conducted in the last two decades on the mechanism of HIV PR and the impact of their conclusions on the drug discovery processes.

Original languageEnglish
Pages (from-to)5-14
Number of pages10
JournalOrganic and Biomolecular Chemistry
Issue number1
StatePublished - 7 Jan 2003
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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