Hla alleles in systemic sclerosis: Association with pulmonary hypertension and outcome

P. Langevitz; D. Buskila; D. D. Gladman; G. A. Darlington; V. T. Farewell; P. Lee

doi:10.1093/rheumatology/31.9.609

Hla alleles in systemic sclerosis: Association with pulmonary hypertension and outcome

P. Langevitz, D. Buskila, D. D. Gladman, G. A. Darlington, V. T. Farewell, P. Lee

Research output: Contribution to journal › Article › peer-review

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Abstract

HLA antigen distribution was studied in 126 patients with systemic sclerosis (SSc) followed prospectively and compared to that of 325 healthy controls. The frequencies of HLA antigens DR3, DR5 and DRw52 were increased in patients with diffuse skin involvement (P = 0.02, 0.05, 0.03). The presence of DRw52 (relative risk [RR]≫≫≫1) and DRw6 (RR = 54.5) was associated with significantly increased risks of a fatal disease outcome with pulmonary hypertension (PHT). In the absence of PHT, DRw252 was inversely associated with the risk of death. These findings indicate an adverse prognosis in SSc when PHT is present in association with DRw52.

Original language	English
Pages (from-to)	609-613
Number of pages	5
Journal	Rheumatology
Volume	31
Issue number	9
DOIs	https://doi.org/10.1093/rheumatology/31.9.609
State	Published - 1 Sep 1992
Externally published	Yes

ASJC Scopus subject areas

Rheumatology
Pharmacology (medical)

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10.1093/rheumatology/31.9.609

Cite this

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title = "Hla alleles in systemic sclerosis: Association with pulmonary hypertension and outcome",

abstract = "HLA antigen distribution was studied in 126 patients with systemic sclerosis (SSc) followed prospectively and compared to that of 325 healthy controls. The frequencies of HLA antigens DR3, DR5 and DRw52 were increased in patients with diffuse skin involvement (P = 0.02, 0.05, 0.03). The presence of DRw52 (relative risk [RR]≫≫≫1) and DRw6 (RR = 54.5) was associated with significantly increased risks of a fatal disease outcome with pulmonary hypertension (PHT). In the absence of PHT, DRw252 was inversely associated with the risk of death. These findings indicate an adverse prognosis in SSc when PHT is present in association with DRw52.",

author = "P. Langevitz and D. Buskila and Gladman, {D. D.} and Darlington, {G. A.} and Farewell, {V. T.} and P. Lee",

note = "Funding Information: This work is supported by a grant from The Physicians' Services Incorporated Foundation.",

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doi = "10.1093/rheumatology/31.9.609",

language = "English",

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TY - JOUR

T1 - Hla alleles in systemic sclerosis

T2 - Association with pulmonary hypertension and outcome

AU - Langevitz, P.

AU - Buskila, D.

AU - Gladman, D. D.

AU - Darlington, G. A.

AU - Farewell, V. T.

AU - Lee, P.

N1 - Funding Information: This work is supported by a grant from The Physicians' Services Incorporated Foundation.

PY - 1992/9/1

Y1 - 1992/9/1

N2 - HLA antigen distribution was studied in 126 patients with systemic sclerosis (SSc) followed prospectively and compared to that of 325 healthy controls. The frequencies of HLA antigens DR3, DR5 and DRw52 were increased in patients with diffuse skin involvement (P = 0.02, 0.05, 0.03). The presence of DRw52 (relative risk [RR]≫≫≫1) and DRw6 (RR = 54.5) was associated with significantly increased risks of a fatal disease outcome with pulmonary hypertension (PHT). In the absence of PHT, DRw252 was inversely associated with the risk of death. These findings indicate an adverse prognosis in SSc when PHT is present in association with DRw52.

AB - HLA antigen distribution was studied in 126 patients with systemic sclerosis (SSc) followed prospectively and compared to that of 325 healthy controls. The frequencies of HLA antigens DR3, DR5 and DRw52 were increased in patients with diffuse skin involvement (P = 0.02, 0.05, 0.03). The presence of DRw52 (relative risk [RR]≫≫≫1) and DRw6 (RR = 54.5) was associated with significantly increased risks of a fatal disease outcome with pulmonary hypertension (PHT). In the absence of PHT, DRw252 was inversely associated with the risk of death. These findings indicate an adverse prognosis in SSc when PHT is present in association with DRw52.

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ER -

Hla alleles in systemic sclerosis: Association with pulmonary hypertension and outcome

Abstract

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UN SDGs

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