HLA DQA1-DQB1 genotypes in Bedouin families with celiac disease

Susan L. Neuhausen, Zvi Weizman, Nicola J. Camp, Khalil Elbedour, Val C. Sheffield, John J. Zone, Rivka Carmi

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Celiac disease (CD) has a strong genetic association with human leukocyte antigens (HLA). The primary susceptibility for CD is HLA-DQA1*05 DQB1*02 (also known as DQ2), with the remainder of cases primarily HLA-DQA1*03 DQB1*03 (also known as DQ8). In a set of nine Bedouin multiplex celiac disease families and one simplex, we genotyped DNA samples at HLA DQA1 and DQB1. Nineteen celiac disease patients had at least one DQA1*05 DQB1*02 genotype (= DQ2), 4 affecteds had the second most common genotype of DQA1*03 DQB1*0302 (= DQ8), 9 were DQ2 and DQ8, and 4 had at least one copy of DQB1*02 without the DQA1*05 genotype. Using transmission disequilibrium testing, we observed a significant over-representation in affecteds of the DQA1*05 DQB1*02 genotype (p = 0.0089), as well as over-representation of the DQA1*03 DQB1*0302 genotype (p = 0.078). The HLA DQA1 DQB1 high-risk genotypes associated with celiac disease are similar in these Bedouin families with CD to what is observed in Northern and Southern Europeans.

Original languageEnglish
Pages (from-to)502-507
Number of pages6
JournalHuman Immunology
Volume63
Issue number6
DOIs
StatePublished - 22 Jun 2002
Externally publishedYes

Keywords

  • Bedouins
  • Celiac disease
  • HLA-DQ

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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