Hollow fiber enzymic reactors for a two substrate process: Analytical modeling and numerical simulations

Galia Salzman, Rafael Tadmor, Serge Guzy, Samuel Sideman, Noah Lotan

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


The use of immobilized enzyme reactors in biotechnology and biomedicine is rapidly expanding. This study concentrates on hollow-fiber (HF) enzymic reactors for continuous, single-pass operation. The enzyme, in a soluble form, is physically confined within the shell section of the reactor and the substrate solution flows through the lumen section of it. We consider here a two-substrate reaction proceeding via the Ping-Pong mechanism, with substrates and reaction products diffusing through the fiber wall. The developed analytical model enables to calculate the expected conversion as a function of the volumetric flow rate, kinetic constants, diffusion coefficients, geometric dimensions of the reactor, the flow regimen in the apparatus and substrates concentrations. The model equations are solved by a numerical procedure and the system performance is simulated. Depending on the operation conditions employed, the reactor is controlled by kinetic processes, diffusion processes, or both.

Original languageEnglish
Pages (from-to)289-299
Number of pages11
JournalChemical Engineering and Processing: Process Intensification
Issue number4-6
StatePublished - 1 Jan 1999
Externally publishedYes


  • Analytical modeling
  • Hollow fiber enzymic reactor
  • Numerical simulations

ASJC Scopus subject areas

  • General Chemistry
  • General Chemical Engineering
  • Energy Engineering and Power Technology
  • Industrial and Manufacturing Engineering


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