Abstract
A combination of two complementary approaches that are widely used to predict protein structure - homology and energy-based methods - is proposed. The algorithm is discussed in detail and is demonstrated to be a useful tool for optimization. The properties of the combination are exemplified on a simple model system: structural optimization of 2D heteropolymers on a square lattice. The algorithm is considerably more efficient than simulated annealing in the system studied. The relevance of the results of the protein folding problem is discussed.
Original language | English |
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Pages (from-to) | 11550-11556 |
Number of pages | 7 |
Journal | Journal of Physical Chemistry |
Volume | 99 |
Issue number | 29 |
DOIs | |
State | Published - 1 Jan 1995 |
Externally published | Yes |
ASJC Scopus subject areas
- General Engineering
- Physical and Theoretical Chemistry