Hormonal regulation of PKC: Estrogen up-regulates PKCη expression in estrogen-responsive breast cancer cells

Galia Karp; Adva Maissel; Etta Livneh

doi:10.1016/j.canlet.2006.02.012

Hormonal regulation of PKC: Estrogen up-regulates PKCη expression in estrogen-responsive breast cancer cells

Galia Karp, Adva Maissel, Etta Livneh

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Protein kinase C (PKC) is involved in several major signal transduction pathways that control gene expression cell growth and differentiation. The PKCη isoform appears as a candidate regulator of mammary gland proliferation or differentiation, as its expression is up-regulated in the mammary gland in the transit from resting to the pregnant state. The purpose of this study was to examine the hormonal regulation of PKCη. Here we show that estradiol specifically up-regulates the expression of PKCη in the estrogen-responsive lines MCF-7 and T47D but not in the estrogen non-responsive line MDA-MB 231. Interestingly, the presence of progesterone, involved in the differentiation of the mammary gland, reduced the estrogen-induced PKCη expression in a time-dependent manner. Thus, our studies suggest that PKCη has an important role in signalling pathways regulating mammary gland proliferation and its development.

Original language	English
Pages (from-to)	173-181
Number of pages	9
Journal	Cancer Letters
Volume	246
Issue number	1-2
DOIs	https://doi.org/10.1016/j.canlet.2006.02.012
State	Published - 8 Feb 2007

Keywords

17-β-estradiol
Breast cancer
MCF7
PKC
PKCη
Progesterone

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.canlet.2006.02.012

Cite this

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title = "Hormonal regulation of PKC: Estrogen up-regulates PKCη expression in estrogen-responsive breast cancer cells",

abstract = "Protein kinase C (PKC) is involved in several major signal transduction pathways that control gene expression cell growth and differentiation. The PKCη isoform appears as a candidate regulator of mammary gland proliferation or differentiation, as its expression is up-regulated in the mammary gland in the transit from resting to the pregnant state. The purpose of this study was to examine the hormonal regulation of PKCη. Here we show that estradiol specifically up-regulates the expression of PKCη in the estrogen-responsive lines MCF-7 and T47D but not in the estrogen non-responsive line MDA-MB 231. Interestingly, the presence of progesterone, involved in the differentiation of the mammary gland, reduced the estrogen-induced PKCη expression in a time-dependent manner. Thus, our studies suggest that PKCη has an important role in signalling pathways regulating mammary gland proliferation and its development.",

keywords = "17-β-estradiol, Breast cancer, MCF7, PKC, PKCη, Progesterone",

author = "Galia Karp and Adva Maissel and Etta Livneh",

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journal = "Cancer Letters",

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T1 - Hormonal regulation of PKC

T2 - Estrogen up-regulates PKCη expression in estrogen-responsive breast cancer cells

AU - Karp, Galia

AU - Maissel, Adva

AU - Livneh, Etta

PY - 2007/2/8

Y1 - 2007/2/8

N2 - Protein kinase C (PKC) is involved in several major signal transduction pathways that control gene expression cell growth and differentiation. The PKCη isoform appears as a candidate regulator of mammary gland proliferation or differentiation, as its expression is up-regulated in the mammary gland in the transit from resting to the pregnant state. The purpose of this study was to examine the hormonal regulation of PKCη. Here we show that estradiol specifically up-regulates the expression of PKCη in the estrogen-responsive lines MCF-7 and T47D but not in the estrogen non-responsive line MDA-MB 231. Interestingly, the presence of progesterone, involved in the differentiation of the mammary gland, reduced the estrogen-induced PKCη expression in a time-dependent manner. Thus, our studies suggest that PKCη has an important role in signalling pathways regulating mammary gland proliferation and its development.

AB - Protein kinase C (PKC) is involved in several major signal transduction pathways that control gene expression cell growth and differentiation. The PKCη isoform appears as a candidate regulator of mammary gland proliferation or differentiation, as its expression is up-regulated in the mammary gland in the transit from resting to the pregnant state. The purpose of this study was to examine the hormonal regulation of PKCη. Here we show that estradiol specifically up-regulates the expression of PKCη in the estrogen-responsive lines MCF-7 and T47D but not in the estrogen non-responsive line MDA-MB 231. Interestingly, the presence of progesterone, involved in the differentiation of the mammary gland, reduced the estrogen-induced PKCη expression in a time-dependent manner. Thus, our studies suggest that PKCη has an important role in signalling pathways regulating mammary gland proliferation and its development.

KW - 17-β-estradiol

KW - Breast cancer

KW - MCF7

KW - PKC

KW - PKCη

KW - Progesterone

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U2 - 10.1016/j.canlet.2006.02.012

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M3 - Article

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AN - SCOPUS:33845605456

SN - 0304-3835

VL - 246

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JO - Cancer Letters

JF - Cancer Letters

IS - 1-2

ER -

Hormonal regulation of PKC: Estrogen up-regulates PKCη expression in estrogen-responsive breast cancer cells

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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