Host defense peptides as new weapons in cancer treatment

N. Papo, Y. Shai

Research output: Contribution to journalReview articlepeer-review

405 Scopus citations

Abstract

In the last decade intensive research has been conducted to determine the role of innate immunity host defense peptides (also termed antimicrobial peptides) in the killing of prokaryotic and eukaryotic cells. Many antimicrobial peptides damage the cellular membrane as part of their killing mechanism. However, it is not clear what makes cancer cells more susceptible to some of these peptides, and what the molecular mechanisms underlying these activities are. Two general mechanisms were suggested: (i) plasma membrane disruption via micellization or pore formation, and (ii) induction of apoptosis via mitochondrial membrane disruption. To be clinically used, these peptides need to combine high and specific anticancer activity with stability in serum. Although so far very limited, new studies have paved the way for promising anticancer host defense peptides with a new mode of action and with a broad spectrum of anticancer activity.

Original languageEnglish
Pages (from-to)784-790
Number of pages7
JournalCellular and Molecular Life Sciences
Volume62
Issue number7-8
DOIs
StatePublished - 1 Apr 2005
Externally publishedYes

Keywords

  • Amphipatic peptides
  • Anticancer peptides
  • Antimicrobial peptides
  • Cytolytic peptides
  • Host defense peptides
  • Lytic peptides
  • Membrane permeabilization
  • Model membranes

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Cellular and Molecular Neuroscience
  • Cell Biology

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