How and why kinetics, thermodynamics, and chemistry induce the logic of biological evolution

Addy Pross, Robert Pascal

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Thermodynamic stability, as expressed by the Second Law, generally constitutes the driving force for chemical assembly processes. Yet, somehow, within the living world most self-organisation processes appear to challenge this fundamental rule. Even though the Second Law remains an inescapable constraint, under energy-fuelled, far-from-equilibrium conditions, populations of chemical systems capable of exponential growth can manifest another kind of stability, dynamic kinetic stability (DKS). It is this stability kind based on time/persistence, rather than on free energy, that offers a basis for understanding the evolutionary process. Furthermore, a threshold distance from equilibrium, leading to irreversibility in the reproduction cycle, is needed to switch the directive for evolution from thermodynamic to DKS. The present report develops these lines of thought and argues against the validity of a thermodynamic approach in which the maximisation of the rate of energy dissipation/entropy production is considered to direct the evolutionary process. More generally, our analysis reaffirms the predominant role of kinetics in the self-organisation of life, which, in turn, allows an assessment of semi-quantitative constraints on systems and environments from which life could evolve.

Original languageEnglish
Pages (from-to)665-674
Number of pages10
JournalBeilstein Journal of Organic Chemistry
Volume13
DOIs
StatePublished - 7 Apr 2017

Keywords

  • Dynamic kinetic stability
  • Kinetic control
  • Origins of life
  • Self-organisation

Fingerprint

Dive into the research topics of 'How and why kinetics, thermodynamics, and chemistry induce the logic of biological evolution'. Together they form a unique fingerprint.

Cite this